N
Nico A. Blom
Researcher at Boston Children's Hospital
Publications - 135
Citations - 9378
Nico A. Blom is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 32, co-authored 103 publications receiving 7759 citations. Previous affiliations of Nico A. Blom include Leiden University Medical Center & Academic Medical Center.
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Journal ArticleDOI
Epicardium-Derived Cells in Development of Annulus Fibrosis and Persistence of Accessory Pathways
Denise P. Kolditz,Maurits C.E.F. Wijffels,Nico A. Blom,Arnoud van der Laarse,Nathan D. Hahurij,Heleen Lie-Venema,Roger R. Markwald,Robert E. Poelmann,Martin J. Schalij,Adriana C. Gittenberger-de Groot +9 more
TL;DR: EPDC outgrowth inhibition may result in marked defects in the fibrous annulus with persistence of large APs, which results in ventricular preexcitation on ECG, which may provide a substrate for postnatally persistent reentrant arrhythmias.
Journal ArticleDOI
Systematic review and meta-analysis of the performance of second-trimester screening for prenatal detection of congenital heart defects
Christine L. van Velzen,Johannes C.F. Ket,Peter M. van de Ven,Nico A. Blom,Nico A. Blom,Monique C. Haak +5 more
TL;DR: The prenatal detection rate of congenital heart defects (CHDs) is increasing, but reported rates vary.
Journal ArticleDOI
GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.
Elisabeth M. Lodder,Pasquelena De Nittis,Pasquelena De Nittis,Charlotte D. Koopman,Charlotte D. Koopman,Wojciech Wiszniewski,Carolina Fischinger Moura de Souza,Najim Lahrouchi,Nicolas Guex,Nicolas Guex,Valerio Napolioni,Federico Tessadori,Leander Beekman,Eline A. Nannenberg,Lamiae Boualla,Nico A. Blom,Wim de Graaff,Maarten Kamermans,Maarten Kamermans,Dario Cocciadiferro,Dario Cocciadiferro,Natascia Malerba,Natascia Malerba,Barbara Mandriani,Barbara Mandriani,Zeynep Coban Akdemir,Richard J. Fish,Mohammad K. Eldomery,Ilham Ratbi,Arthur A.M. Wilde,Teun P. de Boer,William F. Simonds,Marguerite Neerman-Arbez,V. Reid Sutton,V. Reid Sutton,Fernando Kok,James R. Lupski,James R. Lupski,Alexandre Reymond,Connie R. Bezzina,Jeroen Bakkers,Jeroen Bakkers,Giuseppe Merla +42 more
TL;DR: Zebrafish gnb5 knockouts recapitulated the phenotypic spectrum of affected individuals, including cardiac, neurological, and ophthalmological abnormalities, supporting a direct role of GNB5 in the control of heart rate, hypotonia, and vision.
Journal ArticleDOI
Prenatal diagnosis of congenital heart defects: accuracy and discrepancies in a multicenter cohort
C. L. van Velzen,S. A. Clur,Marry E.B. Rijlaarsdam,Eva Pajkrt,Caroline J. Bax,Jaroslav Hruda,C. J. M. de Groot,Nico A. Blom,Nico A. Blom,Monique C. Haak +9 more
TL;DR: To examine the accuracy of fetal echocardiography in diagnosing congenital heart disease (CHD) at the fetal medicine units of three tertiary care centers, a large number of patients were diagnosed with CHD after the second trimester of pregnancy.
Journal ArticleDOI
Deficiency of the vestibular spine in atrioventricular septal defects in human fetuses with down syndrome
TL;DR: Reduced expansion of the vestibular spine derived from the dorsal mesocardium appears to play an important role in the development of AVSD in Down syndrome.