N
Nicolas Baeyens
Researcher at Yale University
Publications - 22
Citations - 2224
Nicolas Baeyens is an academic researcher from Yale University. The author has contributed to research in topics: Radixin & Moesin. The author has an hindex of 13, co-authored 22 publications receiving 1714 citations. Previous affiliations of Nicolas Baeyens include Wellcome Trust Centre for Cell-Matrix Research & Université libre de Bruxelles.
Papers
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Journal ArticleDOI
Endothelial-to-mesenchymal transition drives atherosclerosis progression
Pei-Yu Chen,Lingfeng Qin,Nicolas Baeyens,Guangxin Li,Titilayo Afolabi,Madhusudhan Budatha,George Tellides,Martin A. Schwartz,Michael Simons +8 more
TL;DR: Investigation of the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis demonstrates a link between loss of protective endothelial FGFR signaling, development of EndMT, and progression of Atherosclerosis.
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Endothelial fluid shear stress sensing in vascular health and disease
TL;DR: Viewing atherosclerosis and vascular malformations as instances of pathological morphogenesis provides a unifying perspective that may aid in developing new therapies.
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Integrins in mechanotransduction
Tyler D Ross,Brian Bg Coon,Sanguk Yun,Nicolas Baeyens,Keiichiro Tanaka,Mingxing Ouyang,Martin A. Schwartz +6 more
TL;DR: Effects of forces on organs, tissues, and cells are summarized; recent advances toward understanding molecular mechanisms are discussed; and the role of Integrin-mediated adhesions is discussed.
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Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
Brian Bg Coon,Nicolas Baeyens,Jinah Han,Madhusudhan Budatha,Tyler D Ross,Jennifer S. Fang,Sanguk Yun,Jean-Leon Thomas,Martin A. Schwartz +8 more
TL;DR: VE-cadherin plays a critical role in endothelial shear stress mechanotransduction by interacting with VEGFRs through their transmembrane domains.
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Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
Nicolas Baeyens,Stefania Nicoli,Brian G. Coon,Tyler D Ross,Koen van den Dries,Jinah Han,Holly M. Lauridsen,Cecile O. Mejean,Anne Eichmann,Jean-Leon Thomas,Jay D. Humphrey,Martin A. Schwartz +11 more
TL;DR: Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling, providing direct evidence for a fluid shear stress set point and identifying a mechanism for varying the set point.