Integrins in mechanotransduction
Tyler D Ross,Brian Bg Coon,Sanguk Yun,Nicolas Baeyens,Keiichiro Tanaka,Mingxing Ouyang,Martin A. Schwartz +6 more
TLDR
Effects of forces on organs, tissues, and cells are summarized; recent advances toward understanding molecular mechanisms are discussed; and the role of Integrin-mediated adhesions is discussed.About:Â
This article is published in Current Opinion in Cell Biology.The article was published on 2013-10-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Role of cell adhesions in neural development & Actin cytoskeleton.read more
Citations
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Balancing forces: architectural control of mechanotransduction
TL;DR: Sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
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Basement Membranes: Cell Scaffoldings and Signaling Platforms
TL;DR: Mutations adversely affecting expression of the different structural components are associated with developmental arrest at different stages as well as postnatal diseases of muscle, nerve, brain, eye, skin, vasculature, and kidney.
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Mechanisms of disease: pulmonary arterial hypertension
TL;DR: Perturbations of a number of molecular mechanisms have been described, including pathways involving growth factors, cytokines, metabolic signaling, elastases, and proteases, that may underlie the pathogenesis of the disease.
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Movers and shakers: cell cytoskeleton in cancer metastasis
TL;DR: Improved understanding of how the cytoskeleton and its interacting partners influence tumour cell migration and metastasis has led to the development of novel therapeutics against aggressive and metastatic disease.
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Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment
TL;DR: Different bioengineering tools and microscale/nanoscale devices have been successfully developed to engineer the physical aspects of the cellular microenvironment for stem cells, and these tools and devices have proven extremely powerful for identifying the extrinsic physical factors and their downstream intracellular signaling pathways that control stem cell functions.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
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Environmental sensing through focal adhesions
TL;DR: The mechanisms of such environmental sensing are discussed, based on the finely tuned crosstalk between the assembly of one type of integrin-based adhesion complex, namely focal adhesions, and the forces that are at work in the associated cytoskeletal network owing to actin polymerization and actomyosin contraction.
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Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Bertrand Coste,Jayanti Mathur,Manuela Schmidt,Taryn J. Earley,Sanjeev S. Ranade,Matt Petrus,Adrienne E. Dubin,Ardem Patapoutian,Ardem Patapoutian +8 more
TL;DR: Two genes that encode proteins, Piezo1 and Piezo2, are identified, which are required for mechanically stimulated cation conductance in these cells and in cultured dorsal root ganglion neurons, and it is proposed that Piezos are components of MA cation channels.
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A Tense Situation: Forcing Tumour Progression
TL;DR: The changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.