N
Nicolas Derian
Researcher at French Institute of Health and Medical Research
Publications - 7
Citations - 295
Nicolas Derian is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatocellular carcinoma & Proteome. The author has an hindex of 6, co-authored 7 publications receiving 268 citations. Previous affiliations of Nicolas Derian include University of Paris-Sud & Pasteur Institute.
Papers
More filters
Journal ArticleDOI
Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs
Yenkel Grinberg-Bleyer,David Saadoun,Audrey Baeyens,Fabienne Billiard,Jérémie D. Goldstein,Sylvie Grégoire,Gaëlle H. Martin,Rima Elhage,Nicolas Derian,Wassila Carpentier,Gilles Marodon,David Klatzmann,Eliane Piaggio,Benoît L. Salomon +13 more
TL;DR: It is shown that CD4+ Teff activation strongly boosts the expansion and suppressive activity of Tregs, which may be critical to preventing or limiting the development of autoimmune diseases.
Journal ArticleDOI
Distinct Hepatitis C Virus Core and F Protein Quasispecies in Tumoral and Nontumoral Hepatocytes Isolated via Microdissection
Rodolphe Sobesky,Rodolphe Sobesky,Rodolphe Sobesky,Cyrille Feray,Cyrille Feray,François Rimlinger,François Rimlinger,François Rimlinger,Nicolas Derian,Nicolas Derian,Nicolas Derian,Alexandre Dos Santos,Alexandre Dos Santos,Alexandre Dos Santos,Anne-Marie Roque-Afonso,Anne-Marie Roque-Afonso,Didier Samuel,Didier Samuel,Christian Bréchot,Christian Bréchot,Valérie Thiers,Valérie Thiers,Valérie Thiers +22 more
TL;DR: In tumoral hepatocytes, low‐replicating hepatitis C quasispecies are compartmentalized and more diversified and are subjected to low selective pressure, which supports the importance of core genetic variability in hepatocellular carcinogenesis.
Journal ArticleDOI
Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes
Veronika Vlkova,Ivan Štěpánek,Veronika Hrušková,Filip Šenigl,Veronika Mayerová,Martin Sramek,Jana Símová,Jana Bieblová,Marie Indrová,Tomáš Hejhal,Nicolas Derian,David Klatzmann,Adrien Six,Milan Reiniš +13 more
TL;DR: Comparative transcriptome analysis in distinct MHC class I-deficient cell lines upon their treatment with either IFNγ or epigenetic agents revealed that a set of genes, significantly enriched for the antigen presentation pathway, was regulated in the same manner.
Journal ArticleDOI
Regulatory T Cells Orchestrate Similar Immune Evasion of Fetuses and Tumors in Mice
Djamel Nehar-Belaid,Djamel Nehar-Belaid,Djamel Nehar-Belaid,Tristan Courau,Tristan Courau,Tristan Courau,Nicolas Derian,Nicolas Derian,Nicolas Derian,Laura Florez,Laura Florez,Laura Florez,Maria Grazia Ruocco,Maria Grazia Ruocco,Maria Grazia Ruocco,David Klatzmann +15 more
TL;DR: It is proposed that evolutionarily selected mechanisms that protect mammalian fetuses from immune attack are hijacked to license tumor development.
Journal ArticleDOI
Clinical and multi-omics cross-phenotyping of patients with autoimmune and autoinflammatory diseases: the observational TRANSIMMUNOM protocol.
Roberta Lorenzon,Encarnita Mariotti-Ferrandiz,Caroline Aheng,Claire Ribet,Ferial Toumi,Fabien Pitoiset,Wahiba Chaara,Nicolas Derian,Catherine Johanet,Iannis Drakos,Sophie Harris,Serge Amselem,Francis Berenbaum,Olivier Benveniste,Bahram Bodaghi,Patrice Cacoub,Gilles Grateau,Chloé Amouyal,Agnes Hartemann,David Saadoun,Jérémie Sellam,Philippe Seksik,Harry Sokol,Joe-Elie Salem,Eric Vicaut,Adrien Six,Michelle Rosenzwajg,Claude C.A. Bernard,David Klatzmann +28 more
TL;DR: The TRANSIMMUNOM clinical protocol is designed to revisit the nosology of AIDs by combining basic, clinical and information sciences and aims to uncover important phenotypes that cut across diagnostic groups so as to discover biomarkers and identify novel therapeutic targets.