G
Gaëlle H. Martin
Researcher at New York University
Publications - 40
Citations - 1767
Gaëlle H. Martin is an academic researcher from New York University. The author has contributed to research in topics: FOXP3 & Immune system. The author has an hindex of 19, co-authored 37 publications receiving 1436 citations. Previous affiliations of Gaëlle H. Martin include French Institute of Health and Medical Research & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Luisa Cimmino,Igor Dolgalev,Yubao Wang,Akihide Yoshimi,Gaëlle H. Martin,Jingjing Wang,Victor Ng,Bo Xia,Matthew T. Witkowski,Marisa Mitchell-Flack,Isabella Grillo,Sofia Bakogianni,Delphine Ndiaye-Lobry,Miguel Torres Martin,Maria Guillamot,Robert S. Banh,Mingjiang Xu,Maria E. Figueroa,Ross A. Dickins,Omar Abdel-Wahab,Christopher Y. Park,Aristotelis Tsirigos,Benjamin G. Neel,Iannis Aifantis +23 more
TL;DR: TET-mediated DNA oxidation induced by vitamin C treatment in leukemia cells enhances their sensitivity to PARP inhibition and could provide a safe and effective combination strategy to selectively target TET deficiency in cancer.
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Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs
Yenkel Grinberg-Bleyer,David Saadoun,Audrey Baeyens,Fabienne Billiard,Jérémie D. Goldstein,Sylvie Grégoire,Gaëlle H. Martin,Rima Elhage,Nicolas Derian,Wassila Carpentier,Gilles Marodon,David Klatzmann,Eliane Piaggio,Benoît L. Salomon +13 more
TL;DR: It is shown that CD4+ Teff activation strongly boosts the expansion and suppressive activity of Tregs, which may be critical to preventing or limiting the development of autoimmune diseases.
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Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Daniela A. Braun,Jia Rao,Géraldine Mollet,Géraldine Mollet,David Schapiro,Marie Claire Daugeron,Weizhen Tan,Olivier Gribouval,Olivier Gribouval,Olivia Boyer,Olivia Boyer,Patrick Revy,Patrick Revy,Tilman Jobst-Schwan,Johanna Magdalena Schmidt,Jennifer A. Lawson,Denny Schanze,Shazia Ashraf,Jeremy F.P. Ullmann,Charlotte A. Hoogstraten,Nathalie Boddaert,Nathalie Boddaert,Bruno Collinet,Bruno Collinet,Gaëlle H. Martin,Gaëlle H. Martin,Dominique Liger,Svjetlana Lovric,Mónica Furlano,Mónica Furlano,Mónica Furlano,I. Chiara Guerrera,Oraly Sanchez-Ferras,Jennifer Hu,Anne Claire Boschat,Sylvia Sanquer,Björn Menten,Sarah Vergult,Nina De Rocker,Merlin Airik,Tobias Hermle,Shirlee Shril,Eugen Widmeier,Eugen Widmeier,Heon Yung Gee,Heon Yung Gee,Won-Il Choi,Carolin E. Sadowski,Werner L. Pabst,Jillian K. Warejko,Ankana Daga,Tamara Basta,Verena Matejas,Karin Scharmann,Karin Scharmann,Sandra D. Kienast,Sandra D. Kienast,Babak Behnam,Babak Behnam,Brendan Beeson,Amber Begtrup,Malcolm Bruce,Gaik Siew Ch’ng,Shuan-Pei Lin,Shuan-Pei Lin,Jui Hsing Chang,Chao Huei Chen,Megan T. Cho,Patrick M. Gaffney,Patrick E. Gipson,Chyong Hsin Hsu,Jameela A. Kari,Yu Yuan Ke,Cathy Kiraly-Borri,Wai Ming Lai,Emmanuelle Lemyre,Rebecca O. Littlejohn,Amira Masri,Mastaneh Moghtaderi,Kazuyuki Nakamura,Fatih Ozaltin,Marleen Praet,Chitra Prasad,Agnieszka Prytuła,Elizabeth Roeder,Patrick Rump,Rhonda E. Schnur,Takashi Shiihara,Manish D. Sinha,Neveen A. Soliman,Kenza Soulami,David A. Sweetser,Wen Hui Tsai,Jeng Daw Tsai,Jeng Daw Tsai,Jeng Daw Tsai,Rezan Topaloglu,Udo Vester,David Viskochil,Nithiwat Vatanavicharn,Jessica L. Waxler,Klaas J. Wierenga,Matthias T.F. Wolf,Sik Nin Wong,Sebastian A. Leidel,Sebastian A. Leidel,Gessica Truglio,Peter C. Dedon,Peter C. Dedon,Annapurna Poduri,Shrikant Mane,Richard P. Lifton,Richard P. Lifton,Maxime Bouchard,Peter Kannu,David Chitayat,Daniella Magen,Bert Callewaert,Herman van Tilbeurgh,Martin Zenker,Corinne Antignac,Corinne Antignac,Friedhelm Hildebrandt +122 more
TL;DR: Four new monogenic causes of GAMOS are identified, a link between KEOPS function and human disease is described, and potential pathogenic mechanisms are delineated.
Journal ArticleDOI
Extramedullary relapse in acute promyelocytic leukemia treated with all- trans retinoic acid and chemotherapy
S. de Botton,Miguel A. Sanz,S. Chevret,Hervé Dombret,Gaëlle H. Martin,Xavier Thomas,Joaquín Díaz Mediavilla,Christian Recher,Lionel Adès,B. Quesnel,Philippe Brault,Martin F. Fey,H Wandt,D Machover,Agnès Guerci,Frédéric Maloisel,Anne-Marie Stoppa,Consuelo Rayon,Josep-Maria Ribera,Christine Chomienne,L. Degos,Pierre Fenaux +21 more
TL;DR: EM relapse in APL occurs more frequently in patients with increased WBC counts (⩾10 000/mm3) and carries a poor prognosis, and whether CNS prophylaxis should be systematically performed in Patients with WBC ⩽10 000/MM3 at diagnosis remains to be established.
Journal ArticleDOI
Outcome of patients with acute promyelocytic leukemia failing to front-line treatment with all-trans retinoic acid and anthracycline-based chemotherapy (PETHEMA protocols LPA96 and LPA99): benefit of an early intervention.
Jordi Esteve,Lourdes Escoda,Gaëlle H. Martin,Viñas Rubio,Joaquín Díaz-Mediavilla,Marcos González,Concha Rivas,Concepción Luján Álvarez,J D González San Miguel,Salut Brunet,J F Tomás,Mar Tormo,María-José Sayas,P Sánchez Godoy,Dolors Colomer,Pascual Bolufer,Miguel A. Sanz +16 more
TL;DR: Early institution of salvage therapy at molecular failure, before onset of hematological relapse, is beneficial in APL, and given the poor outcome of HEMrel managed with ATRA and HDAC, use of alternative therapeutic strategies in this setting is warranted.