N
Nicolas Desbenoit
Researcher at University of Bordeaux
Publications - 13
Citations - 759
Nicolas Desbenoit is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Mass spectrometry imaging & Mass spectrometry. The author has an hindex of 9, co-authored 12 publications receiving 604 citations. Previous affiliations of Nicolas Desbenoit include University of Bayreuth & University of Giessen.
Papers
More filters
Journal ArticleDOI
imzML--a common data format for the flexible exchange and processing of mass spectrometry imaging data.
Thorsten Schramm,Alfons Hester,Ivo Klinkert,Jean-Pierre Both,Ron M. A. Heeren,Alain Brunelle,Olivier Laprévote,Nicolas Desbenoit,Marie-France Robbe,Markus Stoeckli,Bernhard Spengler,Andreas Römpp +11 more
TL;DR: The data format imzML was developed to allow the flexible and efficient exchange of MS imaging data between different instruments and data analysis software.
Journal ArticleDOI
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients
Adina N. Lazar,Claudia Bich,Maï Panchal,Nicolas Desbenoit,Vanessa W. Petit,David Touboul,Luce Dauphinot,Catherine Marquer,Olivier Laprévote,Alain Brunelle,Charles Duyckaerts +10 more
TL;DR: Cholesterol overload appears a new and independent alteration of AD cerebral cortex and the structure in which cholesterol accumulates and the mechanism of this accumulation remain to be elucidated.
Journal ArticleDOI
A New Safety Concern for Glaucoma Treatment Demonstrated by Mass Spectrometry Imaging of Benzalkonium Chloride Distribution in the Eye, an Experimental Study in Rabbits
Françoise Brignole-Baudouin,Nicolas Desbenoit,Gregory Hamm,Hong Liang,Jean-Pierre Both,Alain Brunelle,Isabelle Fournier,Vincent Guérineau,Raphael Legouffe,Jonathan Stauber,David Touboul,Maxence Wisztorski,Michel Salzet,Olivier Laprévote,Christophe Baudouin +14 more
TL;DR: The presence of BAK preservative in ocular surface structures as well as in deeper structures involved in glaucoma disease is confirmed and the importance of the safety-first principle for the treatment of glau coma patients is highlighted.
Journal Article
In Vitro and in Vivo Experimental Studies on Trabecular Meshwork Degeneration Induced by Benzalkonium Chloride (An American Ophthalmological Society Thesis)
TL;DR: The hypothesis that antiglaucoma medications, through toxicity of their preservative, may cause further long-term trabecular degeneration and therefore enhance outflow resistance, reducing the impact of IOP-lowering agents is supported.
Journal ArticleDOI
Localisation and quantification of benzalkonium chloride in eye tissue by TOF-SIMS imaging and liquid chromatography mass spectrometry
Nicolas Desbenoit,Isabelle Schmitz-Afonso,Christophe Baudouin,Olivier Laprévote,David Touboul,Françoise Brignole-Baudouin,Alain Brunelle +6 more
TL;DR: The analytical method developed here could therefore be of primary interest in the field of pharmaco-toxicology in order to localise, identify and quantify drugs or xenobiotic compounds present at biological sample surfaces.