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Nicole L. Rosin
Researcher at University of Calgary
Publications - 34
Citations - 1235
Nicole L. Rosin is an academic researcher from University of Calgary. The author has contributed to research in topics: Wound healing & Medicine. The author has an hindex of 15, co-authored 24 publications receiving 810 citations. Previous affiliations of Nicole L. Rosin include University of British Columbia & Dalhousie University.
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Journal ArticleDOI
Collagen structural alterations contribute to stiffening of tissue after split-thickness skin grafting.
Nicole L. Rosin,Natacha A. Agabalyan,Katherine E. Olsen,Giampaol Martufi,Vincent Gabriel,Jeff Biernaskie,Elena S. Di Martino +6 more
TL;DR: The aim was to characterize the changes in the dermal collagen after split thickness grafting that could contribute to a deficit in functionality and serve as a baseline for future studies designed to improve skin function using pharmacological or cell‐based therapies for skin repair.
Journal ArticleDOI
Treatment with activated protein C (aPC) is protective during the development of myocardial fibrosis: an angiotensin II infusion model in mice.
Mryanda J. Sopel,Nicole L. Rosin,Alec Falkenham,Michael Bezuhly,Charles T. Esmon,Charles T. Esmon,Timothy D.G. Lee,Robert S. Liwski,Jean-Francois Légaré +8 more
TL;DR: Data indicates that aPC treatment abrogates the fibrogenic response to AngII, and does not appear to confer protection by stimulating the endothelium but by acting directly on the infiltrating cells, potentially inhibiting migration or activation.
Journal ArticleDOI
Early Fibroblast Progenitor Cell Migration to the AngII-Exposed Myocardium Is Not CXCL12 or CCL2 Dependent as Previously Thought
Alec Falkenham,Mryanda J. Sopel,Nicole L. Rosin,Timothy D.G. Lee,Thomas B. Issekutz,Jean-Francois Légaré +5 more
TL;DR: Early fibrocyte recruitment cannot be inhibited through modulating CXCL12 or CCL2, as previously thought.
Journal ArticleDOI
Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Sarthak Sinha,Holly D. Sparks,Elodie Labit,H. Robbins,Kevin Gowing,Arzina Jaffer,E. Kutluberk,Rohit Arora,Micha Sam Brickman Raredon,L. Cao,Scott Swanson,Peng Jiang,Olivia Hee,Hannah Pope,Matt Workentine,Kiran Todkar,Nilesh Sharma,Shyla K Bharadia,Keerthana Chockalingam,Luiz Gustavo de Almeida,Mike Adam,Laura E. Niklason,S. Steven Potter,Ashley W. Seifert,Antoine Dufour,Vincent Gabriel,Nicole L. Rosin,Ron Stewart,Gregory Muench,R. McCorkell,Janos Matyas,Jeff Biernaskie +31 more
TL;DR: The authors showed that full-thickness injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar, and decoupling of fibroblast-immune interactions as a promising approach to mitigate scar.
Journal ArticleDOI
Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumonia.
John Podstawka,Sarthak Sinha,Carlos H Hiroki,Nicole Sarden,Elise Granton,Elodie Labit,Jung Hwan Kim,Graciela Andonegui,Yuefei Lou,Brendan D. Snarr,Donald C. Sheppard,Donald C. Sheppard,Nicole L. Rosin,Jeff Biernaskie,Bryan G. Yipp +14 more
TL;DR: In this paper, the authors used single-cell RNA sequencing to discover eight IgM+ B cell subsets with unique gene regulatory networks in the lung circulation dominated by transitional type 1 B and type 2 B (T2B) cells.