R
Rohit Arora
Researcher at University of Calgary
Publications - 9
Citations - 210
Rohit Arora is an academic researcher from University of Calgary. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 3 publications receiving 25 citations.
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Journal ArticleDOI
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing
Sepideh Abbasi,Sarthak Sinha,Elodie Labit,Nicole L. Rosin,Grace Yoon,Waleed Rahmani,Arzina Jaffer,Nilesh Sharma,Andrew Hagner,Prajay Shah,Rohit Arora,Jessica Yoon,Anowara Islam,Aya Uchida,ChihKai Chang,Jo Anne Stratton,R. Wilder Scott,Fabio M.V. Rossi,T. Michael Underhill,Jeff Biernaskie,Jeff Biernaskie +20 more
TL;DR: It is shown that hair follicle mesenchymal progenitors make limited contributions to wound repair, and pharmacological modulation of RUNX1 and retinoic acid signaling or genetic deletion of Hic1 within wound-activated fibroblasts was sufficient to modulate healing outcomes, suggesting that reparative fibro Blasts have latent but modifiable regenerative capacity.
Journal ArticleDOI
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19.
Sarthak Sinha,Nicole L. Rosin,Rohit Arora,Elodie Labit,Arzina Jaffer,Leslie Cao,Raquel Farias,Angela P. Nguyen,Luiz Gustavo de Almeida,Antoine Dufour,Amy Bromley,Braedon McDonald,Mark R. Gillrie,Marvin J. Fritzler,Bryan G. Yipp,Jeff Biernaskie +15 more
TL;DR: Using single-cell RNA sequencing and plasma proteomics, this paper found that dexamethasone during severe Coronavirus Disease 2019 (COVID-19) ARDS was associated with expansion of distinct neutrophil states characterized by interferon (IFN) and prostaglandin signaling.
Journal ArticleDOI
Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Sarthak Sinha,Holly D. Sparks,Elodie Labit,H. Robbins,Kevin Gowing,Arzina Jaffer,E. Kutluberk,Rohit Arora,Micha Sam Brickman Raredon,L. Cao,Scott Swanson,Peng Jiang,Olivia Hee,Hannah Pope,Matt Workentine,Kiran Todkar,Nilesh Sharma,Shyla K Bharadia,Keerthana Chockalingam,Luiz Gustavo de Almeida,Mike Adam,Laura E. Niklason,S. Steven Potter,Ashley W. Seifert,Antoine Dufour,Vincent Gabriel,Nicole L. Rosin,Ron Stewart,Gregory Muench,R. McCorkell,Janos Matyas,Jeff Biernaskie +31 more
TL;DR: The authors showed that full-thickness injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar, and decoupling of fibroblast-immune interactions as a promising approach to mitigate scar.
Journal ArticleDOI
Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids
Waleed Rahmani,Hyun Chung,Sarthak Sinha,Maxwell P. Bui-Marinos,Rohit Arora,Arzina Jaffer,Jennifer A. Corcoran,Jeff Biernaskie,Justin Chun +8 more
TL;DR: In this paper , Losartan, an angiotensin II receptor blocker being tested in patients with COVID-19 associated acute kidney injury (COVID-AKI) is a common complication of SARS-CoV-2 infection in hospitalized patients.
Posted ContentDOI
An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amendable to Dexamethasone Therapy
Sarthak Sinha,Nicole L. Rosin,Rohit Arora,Elodie Labit,Arzina Jaffer,Leslie Cao,Raquel Farias,Angela P. Nguyen,Braedon McDonald,Mark R. Gillrie,Marvin J. Fritzler,Bryan G. Yipp,Jeff Biernaskie,Jeff Biernaskie +13 more
TL;DR: In this article, the effects of dexamethasone therapy during severe acute respiratory distress syndrome (ARDS) were investigated and compared to other causes of ARDS, such as bacterial sepsis.