Niculin J. Herz

TL;DR: Analysis of Tcfeb LiKO/Tfe3 double KO mice demonstrated that depletion of both TFE3 and TFEB results in additive effects with an exacerbation of the hepatic phenotype, indicating that TFE 3 and T FEB play a cooperative, rather than redundant, role in the control of the adaptive response of whole‐body metabolism to environmental cues such as diet and physical exercise.

TL;DR: A direct link between nutrient and clock‐dependent regulation of gene expression is revealed shedding a new light on the crosstalk between autophagy, metabolism, and circadian cycles.

TL;DR: It is shown that TFEB regulates the progenitor/cholangiocyte lineage and that its depletion prevents tissue recovery upon injury, identifying an unexplored pathway that controls liver cell lineage commitment and whose dysregulation may play a role in biliary cancer.

TL;DR: This study provides compelling evidence in favor for the use of immunosuppression in all grafted PD patients receiving cell replacement therapy, regardless of the immunological mismatch between donor and host cells, and suggests that cyclosporine treatment itself may act as a disease-modifying therapy in all PD patients.

TL;DR: In this paper , a vesicular trafficking hub connecting the Golgi and lysosome compartments was found to be a link between the M6P-dependent trafficking of lysOSomal enzymes and lysisomal reformation pathway, explaining the global impairment of lysisome function in Batten disease.