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Nikki E. Rossetti
Researcher at Harvard University
Publications - 4
Citations - 1664
Nikki E. Rossetti is an academic researcher from Harvard University. The author has contributed to research in topics: Enhancer & Chromatin. The author has an hindex of 4, co-authored 4 publications receiving 1365 citations. Previous affiliations of Nikki E. Rossetti include Broad Institute.
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Journal ArticleDOI
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Mario L. Suvà,Mario L. Suvà,Mario L. Suvà,Esther Rheinbay,Esther Rheinbay,Esther Rheinbay,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Anoop P. Patel,Anoop P. Patel,Hiroaki Wakimoto,Samuel D. Rabkin,Nicolo Riggi,Nicolo Riggi,Anthony Wei Shine Chi,Daniel P. Cahill,Brian V. Nahed,William T. Curry,Robert L. Martuza,Miguel Rivera,Miguel Rivera,Nikki E. Rossetti,Nikki E. Rossetti,Simon Kasif,Samantha Beik,Sabah Kadri,Itay Tirosh,Ivo Wortman,Alex K. Shalek,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev,David N. Louis,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +37 more
TL;DR: In this paper, a core set of neurodevelopmental transcription factors (POU3F2, SOX2, SALL2, and OLIG2) are identified as essential for GBM propagation.
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Mario L. Suvà,Esther Rheinbay,Shawn M. Gillespie,Anoop P. Patel,Hiroaki Wakimoto,Samuel D. Rabkin,Nicolo Riggi,Andrew S. Chi,Daniel P. Cahill,Brian V. Nahed,William T. Curry,Robert L. Martuza,Miguel Rivera,Nikki E. Rossetti,Simon Kasif,Samantha Beik,Sabah Kadri,Itay Tirosh,Ivo Wortman,Alex K. Shalek,Orit Rozenblatt-Rosen,David N. Louis,Bradley E. Bernstein,Aviv Regev +23 more
TL;DR: This study identifies a core set of neurodevelopmental TFs (POU3F2, SOX2, SALL2, and OLIG2) essential for GBM propagation and reconstructs a network model that highlights critical interactions and identifies candidate therapeutic targets for eliminating TPCs.
Journal ArticleDOI
EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma
Nicolo Riggi,Nicolo Riggi,Birgit Knoechel,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Esther Rheinbay,Esther Rheinbay,Gaylor Boulay,Gaylor Boulay,Mario L. Suvà,Mario L. Suvà,Nikki E. Rossetti,Wannaporn E. Boonseng,Ozgur Oksuz,Edward B. Cook,Aurélie Formey,Anoop P. Patel,Anoop P. Patel,Melissa Gymrek,Melissa Gymrek,Vishal Thapar,Vikram Deshpande,David T. Ting,Francis J. Hornicek,G. Petur Nielsen,Ivan Stamenkovic,Martin J. Aryee,Martin J. Aryee,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein,Miguel Rivera,Miguel Rivera +33 more
TL;DR: Divergent chromatin-remodeling patterns repress tumor suppressors and mesenchymal lineage regulators while activating oncogenes and potential therapeutic targets, such as the kinase VRK1.
Journal ArticleDOI
OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma.
Gaylor Boulay,Gaylor Boulay,Mary E. Awad,Nicolo Riggi,Tenley C. Archer,Tenley C. Archer,Sowmya Iyer,Wannaporn E. Boonseng,Nikki E. Rossetti,Beverly Naigles,Shruthi Rengarajan,Angela Volorio,Angela Volorio,James Kim,Jill P. Mesirov,Jill P. Mesirov,Pablo Tamayo,Pablo Tamayo,Scott L. Pomeroy,Scott L. Pomeroy,Martin J. Aryee,Martin J. Aryee,Miguel Rivera,Miguel Rivera +23 more
TL;DR: Using chromatin profiling, it is found that the transcription factor OTX2 acts as a pioneer factor and, in cooperation with NEUROD1, controls the Group 3 medulloblastoma active enhancer landscape.