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Nikola S. Müller
Researcher at Max Planck Society
Publications - 17
Citations - 496
Nikola S. Müller is an academic researcher from Max Planck Society. The author has contributed to research in topics: microRNA & DNA methylation. The author has an hindex of 8, co-authored 15 publications receiving 344 citations. Previous affiliations of Nikola S. Müller include Helmholtz Zentrum München.
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Journal ArticleDOI
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
Christian Krendl,Dmitry Shaposhnikov,Valentyna Rishko,Chaido Ori,Christoph Ziegenhain,Steffen Sass,Lukas M. Simon,Nikola S. Müller,Tobias Straub,Kelsey E. Brooks,Shawn L. Chavez,Wolfgang Enard,Fabian J. Theis,Micha Drukker +13 more
TL;DR: The discovery of the TEtra circuit indicates how trophectoderm commitment is regulated in human embryogenesis, and provides a mechanistic explanation for the differentiation of trophoblasts from human pluripotent stem cells, a process relying on BMP morphogens.
Journal ArticleDOI
Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops
Tina Freisinger,Ben Klünder,Jared L. Johnson,Nikola S. Müller,Garwin Pichler,Garwin Pichler,Gisela Beck,Michael Costanzo,Charles Boone,Richard A. Cerione,Erwin Frey,Roland Wedlich-Söldner +11 more
TL;DR: This work shows that in the yeast Saccharomyces cerevisiae a combination of actin- and guanine nucleotide dissociation inhibitor-dependent recycling of the central polarity regulator Cdc42 is needed to establish robust cell polarity at a single site during yeast budding.
Journal Article
Glucocorticoid Exposure During Hippocampal Neurogenesis Primes Future Stress Response by Inducing Changes in DNA Methylation: Glucocorticoids induce DNAm changes during neurogenesis
Nadine Provencal,Janine Arloth,Annamaria Cattaneo,Christoph Anacker,Nadia Cattane,Tobias Wiechmann,Simone Röh,Maik Ködel,Torsten Klengel,Darina Czamara,Nikola S. Müller,Jari Lahti,Katri Räikkönen,Carmine M. Pariante,Elisabeth B. Binder,Elisabeth B. Binder +15 more
TL;DR: The data suggest that early exposure to GCs can change the set point of future transcriptional responses to stress by inducing lasting DNAm changes, which may relate to differential vulnerability to stress exposure later in life.
Journal ArticleDOI
MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM
Nina Stojcheva,Gennadi Schechtmann,Steffen Sass,Patrick Roth,Ana-Maria Florea,Anja Stefanski,Kai Stühler,Marietta Wolter,Nikola S. Müller,Fabian J. Theis,Michael Weller,Guido Reifenberger,Guido Reifenberger,Caroline Happold +13 more
TL;DR: In this paper, the role of microRNA alterations as mediators of alkylator resistance in glioblastoma cells was investigated using microarray-based miRNA expression profiling of parental and TMZ-resistant cultures of three human glioma cell lines.
Proceedings ArticleDOI
CoCo: coding cost for parameter-free outlier detection
TL;DR: The basic idea of CoCo relates outlier detection to data compression: Outliers are objects which can not be effectively compressed given the data set, and relies on a very general data model combining the Exponential Power Distribution with Independent Components.