N
Nikolaus Rajewsky
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 190
Citations - 59153
Nikolaus Rajewsky is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 76, co-authored 164 publications receiving 50045 citations. Previous affiliations of Nikolaus Rajewsky include New York University & Rockefeller University.
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The transcriptome dynamics of single cells during the cell cycle
Daniel Schwabe,Sara Formichetti,Jan Philipp Junker,Martin Falcke,Martin Falcke,Nikolaus Rajewsky +5 more
TL;DR: Cells traverse high-dimensional gene expression space in a 2D circular motion, thus minimizing changes of expression changes (“Acceleration”) and uncover a general design principle of the cell cycle that may be of relevance to many other cellular differentiation processes.
Genomes & Developmental Control Computational identification of microRNA targets
TL;DR: This work presents a new computational method that is designed to identify microRNA target sites with high specificity and finds that many key developmental body patterning genes such as hairy and fushi-tarazu are likely to be translationally regulated by microRNAs.
Posted ContentDOI
Prox2+ and Runx3+ neurons regulate esophageal motility
Elijah D. Lowenstein,Pierre-Louis Ruffault,Aristotelis Misios,Kate L Osman,Huimin Li,Rebecca Thompson,Kun Song,Stephan Dietrich,Xun Li,Nikita Vladimirov,Jean-François Brunet,Andrew Woehler,Niccolò Zampieri,Ralf Kühn,Shiqi Jia,Gary R. Lewin,Nikolaus Rajewsky,Teresa E. Lever,Carmen Birchmeier +18 more
TL;DR: This work reveals the identity and function of the vagal neurons that provide mechanosensory feedback from the esophagus to the brain, and could lead to better understanding and treatment of esophageal motility disorders.
Journal ArticleDOI
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids
Agnieszka Rybak-Wolf,Emanuel Wyler,Tancredi Massimo Pentimalli,Ivano Legnini,Petar Glazar,Anna Loewa,Seung Joon Kim,Benedikt B. Kaufer,Andrew Woehler,Markus Landthaler,Nikolaus Rajewsky +10 more
TL;DR: In this article , the authors characterized HSV-1 infection of human brain organoids by combining single-cell RNA sequencing, electrophysiology and immunostaining, and observed strong perturbations of tissue integrity, neuronal function and cellular transcriptomes.
Journal ArticleDOI
Long-term imaging reveals behavioral plasticity during C. elegans dauer exit
TL;DR: WormObserver as mentioned in this paper is an open hardware and software platform for video acquisition, automated processing of large image data and data analysis of C. elegans larva, which can be used for long-term imaging (12h).