N
Nikolaus Rajewsky
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 190
Citations - 59153
Nikolaus Rajewsky is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 76, co-authored 164 publications receiving 50045 citations. Previous affiliations of Nikolaus Rajewsky include New York University & Rockefeller University.
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Cell fixation and preservation for droplet-based single-cell transcriptomics
Jonathan Alles,Nikos Karaiskos,Samantha D. Praktiknjo,Stefanie Grosswendt,Philipp Wahle,Pierre-Louis Ruffault,Salah Ayoub,Luisa Schreyer,Anastasiya Boltengagen,Carmen Birchmeier,Robert P. Zinzen,Christine Kocks,Nikolaus Rajewsky +12 more
TL;DR: It is expected that the availability of a simple cell fixation method will open up many new opportunities to quantitatively analyze transcriptional dynamics at single-cell resolution.
Journal ArticleDOI
Exact results for one-dimensional cellular automata with different types of updates
TL;DR: This work derives explicit relations between the densities and correlation functions for these different stationary states for one-dimensional stochastic cellular automata with arbitrary nearest-neighbor interactions and arbitrary open boundary conditions.
Journal ArticleDOI
Tracing tumorigenesis in a solid tumor model at single-cell resolution
Samantha D. Praktiknjo,Benedikt Obermayer,Benedikt Obermayer,Qionghua Zhu,Qionghua Zhu,Liang Fang,Liang Fang,Haiyue Liu,Hazel M. Quinn,Marlon Stoeckius,Christine Kocks,Walter Birchmeier,Nikolaus Rajewsky +12 more
TL;DR: A cell atlas across tumour development in a genetic model of salivary gland squamous cell carcinoma is provided using single-cell transcriptome and epitope profiling and it is found that cells are connected along a reproducible developmental trajectory.
Journal ArticleDOI
Correlating gene expression variation with cis-regulatory polymorphism in Saccharomyces cerevisiae.
TL;DR: A subset of genes for which changes in predicted TFBSs correlate well with expression divergence between yeast strains are identified, demonstrating both the accuracy of the new TFBS predictions and the feasibility of using simple models of gene regulation to causally link differences in gene expression to variation at individual nucleotides.
Journal ArticleDOI
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Emanuel Wyler,Jennifer Menegatti,Vedran Franke,Christine Kocks,Anastasiya Boltengagen,Thomas Hennig,Kathrin Theil,Andrzej J. Rutkowski,Andrzej J. Rutkowski,Carmelo Ferrai,Laura Baer,Lisa Kermas,Caroline C. Friedel,Nikolaus Rajewsky,Altuna Akalin,Lars Dölken,Friedrich A. Grässer,Markus Landthaler,Markus Landthaler +18 more
TL;DR: It is shown for the first time that a virus induces widespread antisense transcription of the host cell genome and evidence that HSV-1 uses this to downregulate a strong inducer of apoptosis is provided.