N
Nikolaus Rajewsky
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 190
Citations - 59153
Nikolaus Rajewsky is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 76, co-authored 164 publications receiving 50045 citations. Previous affiliations of Nikolaus Rajewsky include New York University & Rockefeller University.
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RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
TL;DR: The application of RCAS on published datasets shows that RCAS is not only able to reproduce published findings but also helps generate novel knowledge and hypotheses.
Posted ContentDOI
MicroRNAs are deeply linked to the emergence of the complex octopus brain
Grygoriy Zolotarov,Bastian Fromm,Ivano Legnini,Salah Ayoub,Gianluca Polese,Valeria Maselli,Peter Chabot,Jakob Vinther,Ruth Styfhals,Eve Seuntjens,Anna Di Cosmo,Kevin J. Peterson,Nikolaus Rajewsky +12 more
TL;DR: It is shown that the major RNA innovation of soft-bodied cephalopods is a massive expansion of the miRNA gene repertoire, and proposed that miRNAs are intimately linked to the evolution of complex animal brains.
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Reexamining microRNA site accessibility in Drosophila: a population genomics study.
TL;DR: A population genomics approach was used to reexamine PITA data and found that the PITA algorithm had lower specificity than methods based on evolutionary conservation at comparable levels of sensitivity, and showed that deeply conserved miRNAs tend to have stronger hybridization energies to their targets than do other mi RNAs.
Journal ArticleDOI
microRNAs and the Operon Paper
TL;DR: The basic principles of gene regulation by miRNAs are reviewed and how these principles can be linked to insights from the Operon paper.
Posted ContentDOI
Charting a tissue from single-cell transcriptomes
TL;DR: A conceptually different approach is presented that allows to reconstruct spatial positions of cells in a variety of tissues without using reference imaging data and shows that this optimization problem can be cast as a generalized optimal transport problem and solved efficiently.