N
Nikolaus Rajewsky
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 190
Citations - 59153
Nikolaus Rajewsky is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 76, co-authored 164 publications receiving 50045 citations. Previous affiliations of Nikolaus Rajewsky include New York University & Rockefeller University.
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Journal ArticleDOI
Select microRNAs are essential for early development in the sea urchin.
Jia L. Song,Marlon Stoeckius,Jonas Maaskola,Marc R. Friedländer,Nadezda A. Stepicheva,Celina E. Juliano,Svetlana Lebedeva,William Thompson,Nikolaus Rajewsky,Gary M. Wessel +9 more
TL;DR: Results indicate that post-transcriptional gene regulation directed by miRNAs is functionally important for early embryogenesis and is an integral part of the early embryonic gene regulatory network in S. purpuratus.
Posted ContentDOI
Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention
Emanuel Wyler,Kirstin Mösbauer,Vedran Franke,Asija Diag,Lina Theresa Gottula,Roberto Arsie,Filippos Klironomos,David Koppstein,Salah Ayoub,Christopher Buccitelli,Anja Richter,Ivano Legnini,Andranik Ivanov,Tommaso Mari,Simone Del Giudice,Jan Papies,Marcel A. Müller,Daniela Niemeyer,Matthias Selbach,Altuna Akalin,Nikolaus Rajewsky,Christian Drosten,Markus Landthaler +22 more
TL;DR: In vitro cell culture models are established to study SARS-CoV-2 infection and heat shock protein 90 (HSP90) protein is identified as a potential drug target for therapeutic intervention of Sars-CoVs infection.
Journal ArticleDOI
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
Robin Graf,Mathias Munschauer,Guido Mastrobuoni,Florian B. Mayr,Udo Heinemann,Stefan Kempa,Nikolaus Rajewsky,Markus Landthaler +7 more
TL;DR: The authors' data suggest that LIN28B directly interacts with most expressed mRNAs and members of the let-7 microRNA family, and that the strength of protein synthesis reduction correlated with the location of Lin28B binding sites within target transcripts.
Journal ArticleDOI
Paternal RNA contributions in the Caenorhabditis elegans zygote
TL;DR: In this article, metabolic labeling was used to show that RNA can be transferred by sperm into the oocyte upon fertilization, which suggests an unexplored paternal contribution to early development.
Journal ArticleDOI
Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians
Jordi Solana,Manuel Irimia,Salah Ayoub,Marta Rodriguez Orejuela,Vera Zywitza,Marvin Jens,Javier Tapial,Debashish Ray,Quaid Morris,Timothy P. Hughes,Benjamin J. Blencowe,Nikolaus Rajewsky +11 more
TL;DR: It is shown that functional antagonism between CELF and MBNL factors directly controls stem cell-specific AS in planarians, placing the origin of this regulatory mechanism at the base of Bilaterians.