N
Nikolaus Rajewsky
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 190
Citations - 59153
Nikolaus Rajewsky is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 76, co-authored 164 publications receiving 50045 citations. Previous affiliations of Nikolaus Rajewsky include New York University & Rockefeller University.
Papers
More filters
Journal ArticleDOI
Spatial particle condensation for an exclusion process on a ring
TL;DR: In this paper, the stationary state of a simple exclusion process on a ring was studied and it was shown that in the framework of a grand canonical ensemble there is no phase transition from a mixed phase to a disordered phase.
Journal ArticleDOI
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Emanuel Wyler,Vedran Franke,Jennifer Menegatti,Christine Kocks,Anastasiya Boltengagen,Samantha D. Praktiknjo,Barbara Walch-Rückheim,Jens B. Bosse,Nikolaus Rajewsky,Friedrich A. Grässer,Altuna Akalin,Markus Landthaler,Markus Landthaler +12 more
TL;DR: The authors profile the transcriptomes of individual HSV-1-infected human fibroblasts and provide evidence of an antiviral program mediated by the activation of the host transcription factorNRF2, suggesting that NRF2 activation restricts viral infection.
Posted ContentDOI
The Drosophila Embryo at Single Cell Transcriptome Resolution
Nikos Karaiskos,Philipp Wahle,Jonathan Alles,Anastasiya Boltengagen,Salah Ayoub,Claudia Kipar,Christine Kocks,Nikolaus Rajewsky,Robert P. Zinzen +8 more
TL;DR: A ‘transcriptomic blueprint’ of development is produced – a virtual embryo where 3D locations of sequenced cells are confidently identified and DVEX is believed to be a prototype for powerful single cell studies in complex tissues.
Journal ArticleDOI
Translational regulation shapes the molecular landscape of complex disease phenotypes
Sebastian Schafer,Sebastian Schafer,Eleonora Adami,Matthias Heinig,Matthias Heinig,Katharina E Costa Rodrigues,Franziska Kreuchwig,Jan Silhavy,Sebastiaan van Heesch,Deimante Simaite,Nikolaus Rajewsky,Edwin Cuppen,Michal Pravenec,Martin Vingron,Stuart A. Cook,Stuart A. Cook,Stuart A. Cook,Norbert Hubner,Norbert Hubner +18 more
TL;DR: It is shown that a large number of genes associated with heart and liver traits in human genome-wide association studies are primarily translationally regulated, almost doubling the number of differentially expressed genes.
Journal ArticleDOI
Epigenetic dynamics of monocyte-to-macrophage differentiation
Stefan Wallner,Christopher Schröder,Elsa Leitão,Tea Berulava,Claudia Haak,Daniela Beißer,Sven Rahmann,Andreas S. Richter,Thomas Manke,Ulrike Bönisch,Laura Arrigoni,Sebastian Fröhler,Filippos Klironomos,Wei Chen,Nikolaus Rajewsky,Fabian Müller,Peter Ebert,Thomas Lengauer,Matthias Barann,Philip Rosenstiel,Gilles Gasparoni,Karl Nordström,Jörn Walter,Benedikt Brors,Gideon Zipprich,Bärbel Felder,Ludger Klein-Hitpass,Corinna Attenberger,Gerd Schmitz,Bernhard Horsthemke +29 more
TL;DR: A phagocytic gene network is discovered that is repressed by DNA methylation in monocytes and rapidly de-repressed after the onset of macrophage differentiation.