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Nissi Varki
Researcher at University of California, San Diego
Publications - 193
Citations - 18035
Nissi Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & Antibody. The author has an hindex of 75, co-authored 188 publications receiving 16502 citations. Previous affiliations of Nissi Varki include University of California, Berkeley & University of Chicago.
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Distinct Selectin Ligands on Colon Carcinoma Mucins Can Mediate Pathological Interactions among Platelets, Leukocytes, and Endothelium
TL;DR: It is shown that the three recombinant soluble selectins recognize ligands within primary colon carcinoma tissue samples and that the selectin ligands on purified carcinoma mucins can mediate at least four different pathological interactions among platelets, leukocytes, and endothelial cells.
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Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.
TL;DR: Analysis of genomic regions surrounding the Siglec-11 gene suggests that it is actually a chimeric molecule that arose from relatively recent gene duplication and recombination events, involving the extracellular domain of a closely related ancestral SigleC gene and a transmembrane and cytosolic tail derived from another ancestral SigLec.
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Ras activation in human breast cancer
F. C. Von Lintig,Anna Dreilinger,Nissi Varki,Anne M. Wallace,Darren E. Casteel,Gerry R. Boss +5 more
TL;DR: Ras was abnormally activated in breast cancers overexpressing the EGF and/or ErbB-2 receptors indicating there are sufficient ligands in vivo to activate these receptors, and this work provides a basis for new target-based treatments of this disease.
Journal Article
Antigens Associated with a Human Lung Adenocarcinoma Defined by Monoclonal Antibodies
TL;DR: Investigation of monoclonal antibodies developed in this laboratory from a fusion of the murine myeloma cell line P3X63Ag8 with spleens of BALB/c mice found them to be reactive with adenocarcinomas of the lung and not with the other histological types of lung carcinoma or normal tissue.
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Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection
Vivekanand Datta,Sandra M. Myskowski,Laura A. Kwinn,Daniel N. Chiem,Nissi Varki,Rita Kansal,Malak Kotb,Victor Nizet +7 more
TL;DR: It is concluded that all genetic components of the sag operon are required for expression of functional SLS, an important virulence factor in the pathogenesis of invasive M1T1 GAS infection.