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Nissi Varki
Researcher at University of California, San Diego
Publications - 193
Citations - 18035
Nissi Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & Antibody. The author has an hindex of 75, co-authored 188 publications receiving 16502 citations. Previous affiliations of Nissi Varki include University of California, Berkeley & University of Chicago.
Papers
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Journal Article
A novel detection system for submicroscopic human metastases in athymic mice.
TL;DR: A sensitive assay system to accurately detect the amount of human tumor DNA, if present, in athymic mouse organs is developed and may now be used to confirm the presence or absence of human neoplasm metastases in the athymi mouse model system.
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Esophageal Submucosal Injection of Capsaicin but Not Acid Induces Symptoms in Normal Subjects.
TL;DR: The mechanism of acid-induced heartburn and chest pain is not the simple interaction of hydrogen ions with afferents located in the esophageal mucosa and submucosa, but rather the direct activation of TRPV1 by capsaicin.
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Endothelial cells enhance spontaneous metastasis of human lung carcinoma cells in athymic mice.
TL;DR: The enhanced ability of a metastatic variant, MV522, of a human lung carcinoma cell line to adhere to endothelial cell monolayers is demonstrated and the ability to spontaneously metastasize from subcutaneous sites in athymic mice, of in vitro selected endothelial adhesive subpopulations of MV522 is shown.
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Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis.
Gregory J. Golden,Alejandro Gomez Toledo,Alejandro Gomez Toledo,Alex Marki,James T. Sorrentino,Claire Morris,Raquel J Riley,Charlotte B. Spliid,Qiongyu Chen,Ingrid Cornax,Nathan E. Lewis,Nathan E. Lewis,Nissi Varki,Dzung T. Le,Johan Malmström,Christofer Karlsson,Klaus Ley,Klaus Ley,Victor Nizet,Victor Nizet,Jeffrey D. Esko +20 more
TL;DR: In this article, the authors demonstrate that rapid proteome remodeling of the vascular surfaces precedes hepatic damage in a murine model of Staphylococcus aureus sepsis using a chemical tagging workflow and high-resolution mass spectrometry.
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Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness
TL;DR: This paper examines genes influencing cognitive decline in postreproductive humans, which arises from neurodegenerative and cardiovascular disease, and found many protective alleles that are derived from and are unique to the human lineage.