N
NM Nicole Hijnen
Researcher at Eindhoven University of Technology
Publications - 11
Citations - 851
NM Nicole Hijnen is an academic researcher from Eindhoven University of Technology. The author has contributed to research in topics: Drug delivery & Biodistribution. The author has an hindex of 10, co-authored 11 publications receiving 758 citations.
Papers
More filters
Journal ArticleDOI
Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study
TL;DR: Temperature-sensitive liposomes co-encapsulating doxorubicin and 250 mM [Gd(HPDO3A)(H₂O)] were evaluated for HIFU-mediated drug delivery under MR image guidance and a good correlation between the ΔR₁, the uptake and the gadolinium concentration in the tumor was found.
Journal ArticleDOI
Magnetic resonance guided high-intensity focused ultrasound for image-guided temperature-induced drug delivery
TL;DR: This review focuses on MR-HIFU as a noninvasive technology platform, temperature-sensitive liposomal formulations for drug delivery and image-guided drug delivery, and the effect of HIFU-induced hyperthermia on the TSL and drug distribution.
Journal ArticleDOI
Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound
NM Nicole Hijnen,Ecm Esther Kneepkens,Mariska de Smet,Sander Langereis,Edwin Heijman,Holger Grüll +5 more
TL;DR: The combination of hyperthermia-triggered drug delivery followed by ablation showed the best therapeutic outcome compared with all other treatment groups due to direct induction of thermal necrosis in the tumor core and efficient drug delivery to the tumor rim.
Journal ArticleDOI
Tumour hyperthermia and ablation in rats using a clinical MR-HIFU system equipped with a dedicated small animal set-up.
NM Nicole Hijnen,Edwin Heijman,Max O. Köhler,Mika Petri Ylihautala,Gosta J. Ehnholm,Arjan W. Simonetti,Holger Grüll +6 more
TL;DR: The results demonstrated that, by using a designated set‐up, both controlled hyperthermia and thermal ablation treatment of malignant tumours in rodents can be performed on a clinical MR‐HIFU system.
Journal ArticleDOI
SPECT/CT imaging of temperature-sensitive liposomes for MR-image guided drug delivery with high intensity focused ultrasound
Mariska de Smet,Sander Langereis,Sandra M. van den Bosch,Katrin Bitter,NM Nicole Hijnen,Edwin Heijman,Holger Grüll,Holger Grüll +7 more
TL;DR: The effects of HIFU-treated tumors showed 4.4 times higher liposome uptake after 48 h in comparison with controls, while the doxorubicin concentration was increased by a factor of 7.9.