E
Edwin Heijman
Researcher at Philips
Publications - 37
Citations - 1260
Edwin Heijman is an academic researcher from Philips. The author has contributed to research in topics: Drug delivery & Control theory. The author has an hindex of 13, co-authored 33 publications receiving 1124 citations. Previous affiliations of Edwin Heijman include Eindhoven University of Technology & University of Cologne.
Papers
More filters
Journal ArticleDOI
Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study
TL;DR: Temperature-sensitive liposomes co-encapsulating doxorubicin and 250 mM [Gd(HPDO3A)(H₂O)] were evaluated for HIFU-mediated drug delivery under MR image guidance and a good correlation between the ΔR₁, the uptake and the gadolinium concentration in the tumor was found.
Journal ArticleDOI
Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse.
Gustav J. Strijkers,Annemiek Bouts,W. Matthijs Blankesteijn,T.H.J.M. Peeters,Anna Vilanova,Mischa C. van Prooijen,Honorius M. H. F. Sanders,Edwin Heijman,Klaas Nicolay +8 more
TL;DR: DTI provides a valuable non‐destructive tool for characterizing structural remodeling in diseased myocardium using diffusion tensor imaging in a mouse model of myocardial infarction.
Journal ArticleDOI
A Digital Preclinical PET/MRI Insert and Initial Results
Bjoern Weissler,Pierre Gebhardt,Peter Michael Dueppenbecker,Jakob Wehner,David Schug,Christoph Lerche,Benjamin Goldschmidt,Andre Salomon,Iris Verel,Edwin Heijman,Michael Perkuhn,Dirk Heberling,René M. Botnar,Fabian Kiessling,Volkmar Schulz +14 more
TL;DR: Digital Silicon Photomultipliers are the digital evolution in scintillation light detector technology and promise high PET SNR and cardiac- and respiratory-gated PET/MRI motion-capturing images of the mouse heart demonstrate the advantage of simultaneous acquisition for temporal and spatial image registration.
Journal ArticleDOI
Comparison between prospective and retrospective triggering for mouse cardiac MRI.
Edwin Heijman,Wolter L. de Graaf,Petra Niessen,Arno Nauerth,Guillaume J.J.M. van Eys,Larry de Graaf,Klaas Nicolay,Gustav J. Strijkers +7 more
TL;DR: This study presents a Cartesian CINE MRI protocol based on a fast low‐angle shot sequence with a navigator echo to generate cardiac triggering and respiratory gating signals retrospectively, making the use of ECG leads and respiratory motion sensors obsolete.
Journal ArticleDOI
Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound
NM Nicole Hijnen,Ecm Esther Kneepkens,Mariska de Smet,Sander Langereis,Edwin Heijman,Holger Grüll +5 more
TL;DR: The combination of hyperthermia-triggered drug delivery followed by ablation showed the best therapeutic outcome compared with all other treatment groups due to direct induction of thermal necrosis in the tumor core and efficient drug delivery to the tumor rim.