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Nobuyuki Shimono
Researcher at Kyushu University
Publications - 113
Citations - 2025
Nobuyuki Shimono is an academic researcher from Kyushu University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 19, co-authored 86 publications receiving 1421 citations.
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Journal ArticleDOI
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.
Chihiro Motozono,Mako Toyoda,Jiri Zahradnik,Akatsuki Saito,Hesham Nasser,Toong Seng Tan,Isaac Ngare,Izumi Kimura,Keiya Uriu,Yusuke Kosugi,Yuan Yue,Ryo Shimizu,Jumpei Ito,Shiho Torii,Akiko Yonekawa,Nobuyuki Shimono,Yoji Nagasaki,Rumi Minami,Takashi Toya,Noritaka Sekiya,Takasuke Fukuhara,Yoshiharu Matsuura,Gideon Schreiber,Terumasa Ikeda,So Nakagawa,Takamasa Ueno,Kei Sato +26 more
TL;DR: In this article, two recently emerging mutations in the receptor-binding domain of the SARS-CoV-2 spike protein, L452R and Y453F, are shown to increase spike stability, virus infectivity, and fusogenicity.
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Changing Trends in Antimicrobial Resistance and Serotypes of Streptococcus pneumoniae Isolates in Asian Countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study
So Hyun Kim,Jae-Hoon Song,Doo Ryeon Chung,Visanu Thamlikitkul,Yonghong Yang,Hui Wang,Min Lu,Thomas Man-kit So,Po-Ren Hsueh,Rohani Md Yasin,Celia C. Carlos,Hung Van Pham,M. K. Lalitha,Nobuyuki Shimono,Jennifer Perera,Atef M. Shibl,Jin Yang Baek,Cheol-In Kang,Kwan Soo Ko,Kyong Ran Peck +19 more
TL;DR: The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A.
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Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins.
Yoshihiro Eriguchi,Shuichiro Takashima,Hideyo Oka,Sonoko Shimoji,Kiminori Nakamura,Hidetaka Uryu,Shinji Shimoda,Hiromi Iwasaki,Nobuyuki Shimono,Tokiyoshi Ayabe,Koichi Akashi,Takanori Teshima +11 more
TL;DR: The novel mechanism responsible for shift in the gut flora from commensals toward the widespread prevalence of pathogens and the previously unrecognized association between GVHD and infection after allogeneic SCT is revealed.
Journal ArticleDOI
Current epidemiology, genetic evolution and clinical impact of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae
TL;DR: Careful therapeutic selection and continued surveillance for the detection of multidrug-resistant bacteria are required for the development of therapies against multi-drug resistant bacteria.
Journal ArticleDOI
Community spread of extended-spectrum β-lactamase-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis: a long-term study in Japan
Yong Chong,Shinji Shimoda,Hiroko Yakushiji,Yoshikiyo Ito,Toshihiro Miyamoto,Tomohiko Kamimura,Nobuyuki Shimono,Koichi Akashi +7 more
TL;DR: It is believed to be the first report from Japan showing a definite increase in ESBL detection in outpatients and the findings suggest the simultaneous community spread of diverse ESBL genotypes, not an expansion of particular ESBL genes.