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Noemie Gardiol
Researcher at Ludwig Institute for Cancer Research
Publications - 3
Citations - 684
Noemie Gardiol is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Wnt signaling pathway & T cell. The author has an hindex of 3, co-authored 3 publications receiving 608 citations.
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Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
Grégoire Jeannet,Caroline Boudousquié,Noemie Gardiol,Joonsoo Kang,Joerg Huelsken,Werner Held +5 more
TL;DR: It is shown that mice lacking T cell factor 1 (Tcf-1), a nuclear effector of the canonical Wingless/Integration 1 (Wnt) signaling pathway, mount normal effector and effector memory CD8 T cell responses to infection with lymphocytic choriomeningitis virus, demonstrating that the canonical Wnt signaling pathway plays an essential role for CD8 central memory T cell differentiation under physiological conditions in vivo.
Journal ArticleDOI
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Grégoire Jeannet,Marina Scheller,Leonardo Scarpellino,Stéphane Duboux,Noemie Gardiol,Jonathan Back,Fabien Kuttler,Ilaria Malanchi,Walter Birchmeier,Achim Leutz,Joerg Huelsken,Werner Held +11 more
TL;DR: Ex vivo reporter gene assays provide the first evidence that hematopoietic cells can transduce canonical Wnt signals in the combined absence of beta- and gamma-catenin, and show that Wnt signal transmission is maintained in double-deficient hematoplastic stem cells, thymocytes, or peripheral T cells.
Journal ArticleDOI
Regulation of γδ Versus αß T Lymphocyte Differentiation by the Transcription Factor SOX13
Heather J. Melichar,Kavitha Narayan,Sandy D. Der,Yoshiki Hiraoka,Noemie Gardiol,Grégoire Jeannet,Werner Held,Cynthia A. Chambers,Joonsoo Kang +8 more
TL;DR: Using Sox13 transgenic mice, it is shown that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation, revealing a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.