K
Kavitha Narayan
Researcher at University of Massachusetts Medical School
Publications - 14
Citations - 981
Kavitha Narayan is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 11, co-authored 14 publications receiving 810 citations.
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Journal ArticleDOI
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Kavitha Narayan,Katelyn Sylvia,Nidhi Malhotra,Catherine C. Yin,Gregory W. Martens,Therese Vallerskog,Hardy Kornfeld,Na Xiong,Nadia Cohen,Michael B. Brenner,Leslie J. Berg,Joonsoo Kang +11 more
TL;DR: A high-resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated on the basis of use of the TCR γ-chain or δ-chain indicated the existence of three separate subtypes of γ δ effector cells in the thymus, each distinguished by unique transcription-factor modules that program effector function.
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Kavitha Narayan,Katelyn E Sylvia,Nidhi Malhotra,Catherine C. Yin,Gregory W. Martens,Therese Vallerskog,Hardy Kornfeld,Na Xiong,Nadia R Cohen,Michael B. Brenner,Leslie J. Berg,Joonsoo Kang,Yan Zhou,Susan A. Shinton,Richard R. Hardy,Natalie A. Bezman,Joseph C. Sun,Charles C. Kim,Lewis L. Lanier,Jennifer Miller,Brian D. Brown,Miriam Merad,Anne L. Fletcher,Kutlu G. Elpek,Angelique Bellemare-Pelletier,Deepali Malhotra,Shannon J. Turley,Katelyn Sylvia,Roi Gazit,Brian S. Garrison,Derrick J. Rossi,Vladimir Jojic,Daphne Koller,Radu Jianu,David H. Laidlaw,James C. Costello,James J. Collins,Nadia Cohen,Patrick J. Brennan,Michael Brenner,Tal Shay,Aviv Regev,Francis Kim,Tata Nageswara Rao,Amy J. Wagers,Emmanuel L. Gautier,Claudia Jakubzick,Gwendalyn J. Randolph,Paul A. Monach,Adam J Best,Jamie Knell,Ananda W. Goldrath,Tracy Heng,Taras Kreslavsky,Michio W. Painter,Diane Mathis,Christophe Benoist +56 more
Journal ArticleDOI
Regulation of γδ Versus αß T Lymphocyte Differentiation by the Transcription Factor SOX13
Heather J. Melichar,Kavitha Narayan,Sandy D. Der,Yoshiki Hiraoka,Noemie Gardiol,Grégoire Jeannet,Werner Held,Cynthia A. Chambers,Joonsoo Kang +8 more
TL;DR: Using Sox13 transgenic mice, it is shown that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation, revealing a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.
Journal ArticleDOI
A Network of High-Mobility Group Box Transcription Factors Programs Innate interleukin-17 Production
Nidhi Malhotra,Kavitha Narayan,Ok Hyun Cho,Katelyn Sylvia,Catherine C. Yin,Heather J. Melichar,M. Rashighi,Véronique Lefebvre,John E. Harris,Leslie J. Berg,Joonsoo Kang +10 more
TL;DR: It is demonstrated that Tγδ17 cells are programmed by a gene regulatory network consisting of a quartet of high-mobility group (HMG) box transcription factors,SOX4, SOX13, TCF 1, and LEF1, and not by conventional TCR signaling.
Journal ArticleDOI
TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production
Kavitha Narayan,Lisa Waggoner,Serena T. Pham,Gabriel L. Hendricks,Stephen N. Waggoner,Joseph E. Conlon,Jennifer P. Wang,Katherine A. Fitzgerald,Joonso Kang +8 more
TL;DR: It is demonstrated that expression of the gene tripartite motif 13 (Trim13) is upregulated in response to inducers of type I IFN and that TRIM13 interacts with both MDA5 and RIG-I in vitro, which places it at a key junction within the viral response pathway.