Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
Grégoire Jeannet,Caroline Boudousquié,Noemie Gardiol,Joonsoo Kang,Joerg Huelsken,Werner Held +5 more
Reads0
Chats0
TLDR
It is shown that mice lacking T cell factor 1 (Tcf-1), a nuclear effector of the canonical Wingless/Integration 1 (Wnt) signaling pathway, mount normal effector and effector memory CD8 T cell responses to infection with lymphocytic choriomeningitis virus, demonstrating that the canonical Wnt signaling pathway plays an essential role for CD8 central memory T cell differentiation under physiological conditions in vivo.Citations
More filters
Journal ArticleDOI
A human memory T cell subset with stem cell-like properties
Luca Gattinoni,Enrico Lugli,Yun Ji,Zoltan Pos,Chrystal M. Paulos,Máire F. Quigley,Máire F. Quigley,Jorge R. Almeida,Emma Gostick,Zhiya Yu,Carmine Carpenito,Ena Wang,Daniel C. Douek,David Price,David Price,Carl H. June,Francesco M. Marincola,Mario Roederer,Nicholas P. Restifo +18 more
TL;DR: A long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells is described.
Journal ArticleDOI
Transcriptional control of effector and memory CD8 + T cell differentiation
Susan M. Kaech,Weiguo Cui +1 more
TL;DR: Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8+ T cells have started to be characterized, and this Review discusses the major advances in these areas.
Journal ArticleDOI
CD8+ T Cells: Foot Soldiers of the Immune System
Nu Zhang,Michael J. Bevan +1 more
TL;DR: Recent advances in CD8+ T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery are reviewed, and how CD8-T cell expansion and differentiation are controlled in these contexts are reviewed.
Journal ArticleDOI
Can we safely target the WNT pathway
TL;DR: The problems and potential solutions to the vexing situation of aberrant regulation of the WNT pathway are examined and a attempt is made to bring them into perspective.
Journal ArticleDOI
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
Imran Siddiqui,Karin Schaeuble,Vijaykumar Chennupati,Silvia A. Fuertes Marraco,Sandra Calderon-Copete,Daniela Pais Ferreira,Santiago J. Carmona,Santiago J. Carmona,Santiago J. Carmona,Leonardo Scarpellino,David Gfeller,David Gfeller,David Gfeller,Sylvain Pradervand,Sanjiv A. Luther,Daniel E. Speiser,Werner Held +16 more
TL;DR: This work identified a subset of tumor‐reactive TILs bearing hallmarks of exhausted cells and central memory cells, including expression of the checkpoint protein PD‐1 and the transcription factor Tcf1 that promote tumor control in response to vaccination and checkpoint blockade immunotherapy.
References
More filters
Journal ArticleDOI
Wnt signalling in stem cells and cancer
Tannishtha Reya,Hans Clevers +1 more
TL;DR: Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
Journal ArticleDOI
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.
Nikhil S. Joshi,Weiguo Cui,Anmol Chandele,Heung Kyu Lee,David Urso,James Hagman,Laurent Gapin,Susan M. Kaech +7 more
TL;DR: A mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and regulates their memory cell potential is elucidated.
Journal ArticleDOI
CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes
Edith M. Janssen,Edward E. Lemmens,Tom Wolfe,Urs Christen,Matthias von Herrath,Stephen P. Schoenberger +5 more
TL;DR: The results demonstrate that T-cell help is ‘programmed’ into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen.
Journal ArticleDOI
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells.
Susan M. Kaech,Rafi Ahmed +1 more
TL;DR: Data indicate that initial antigen encounter triggers an instructive developmental program that does not require further antigenic stimulation and does not cease until memory CD8+ T cell formation.
Journal ArticleDOI
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Joseph C. Sun,Michael J. Bevan +1 more
TL;DR: A previously undescribed role for CD4 help in promoting protective CD8 memory development is highlighted in mice that lack CD4+ T cells that mount a primary CD8 response to Listeria monocytogenes.
Related Papers (5)
Defining CD8 + T cells that provide the proliferative burst after PD-1 therapy
Transcriptional control of effector and memory CD8 + T cell differentiation
Susan M. Kaech,Weiguo Cui +1 more
Effector and memory CD8 + T cell fate coupled by T-bet and eomesodermin
Andrew M. Intlekofer,Naofumi Takemoto,E. John Wherry,E. John Wherry,Sarah A. Longworth,John T Northrup,Vikram R. Palanivel,Alan C. Mullen,Christopher R Gasink,Susan M. Kaech,Susan M. Kaech,Joseph D. Miller,Laurent Gapin,Kenneth Ryan,Andreas Russ,Tullia Lindsten,Jordan S. Orange,Ananda W. Goldrath,Ananda W. Goldrath,Rafi Ahmed,Steven L. Reiner +20 more