Joonsoo Kang

TL;DR: The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells.

TL;DR: It is shown that mice lacking T cell factor 1 (Tcf-1), a nuclear effector of the canonical Wingless/Integration 1 (Wnt) signaling pathway, mount normal effector and effector memory CD8 T cell responses to infection with lymphocytic choriomeningitis virus, demonstrating that the canonical Wnt signaling pathway plays an essential role for CD8 central memory T cell differentiation under physiological conditions in vivo.

TL;DR: It is demonstrated that in vivo regulation of Ctla4−/− T cells in trans by CTLA-4–sufficient T cells is a reversible process that requires the persistent presence of FOXP3+ regulatory T cells with a diverse TCR repertoire.

TL;DR: It is shown here that lack of CTLA-4 in regulatory T cells leads to aberrant activation and expansion of conventional T cells, however, CTla-4 expression inventional T cells prevents aberrantly activated T cells from infiltrating and fatally damaging nonlymphoid tissues.

TL;DR: An unexpected function of RIPK3 is revealed in NF-κB activation, DC biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.