N
Noga Bloushtain-Qimron
Researcher at Harvard University
Publications - 11
Citations - 2887
Noga Bloushtain-Qimron is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 11, co-authored 11 publications receiving 2670 citations. Previous affiliations of Noga Bloushtain-Qimron include University of Michigan & Ben-Gurion University of the Negev.
Papers
More filters
Journal ArticleDOI
Molecular Definition of Breast Tumor Heterogeneity
Michail Shipitsin,Lauren L. Campbell,Pedram Argani,Stanislawa Weremowicz,Noga Bloushtain-Qimron,Jun Yao,Tatiana Nikolskaya,Tatiana Serebryiskaya,Rameen Beroukhim,Min Hu,Marc K. Halushka,Saraswati Sukumar,Leroy M. Parker,Karen S. Anderson,Lyndsay Harris,Judy Garber,Andrea L. Richardson,Stuart J. Schnitt,Yuri Nikolsky,Rebecca Gelman,Kornelia Polyak +20 more
TL;DR: In this paper, gene expression and genetic profiles of cells purified from cancerous and normal breast tissue using markers previously associated with stem-cell-like properties were determined using markers from the TGF-β pathway, where its inhibition induced a more epithelial phenotype.
Journal ArticleDOI
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Lauren L. C. Marotta,Vanessa Almendro,Vanessa Almendro,Andriy Marusyk,Michail Shipitsin,Janina Schemme,Sarah R. Walker,Noga Bloushtain-Qimron,Jessica J. Kim,Sibgat Choudhury,Reo Maruyama,Zhenhua Wu,Mithat Gonen,Laura Mulvey,Marina Bessarabova,Sung Jin Huh,Serena J. Silver,So Young Kim,So Young Kim,So Yeon Park,Hee Eun Lee,Karen S. Anderson,Andrea L. Richardson,Tatiana Nikolskaya,Yuri Nikolsky,X. Shirley Liu,David E. Root,William C. Hahn,William C. Hahn,David A. Frank,Kornelia Polyak +30 more
TL;DR: The IL-6/JAK2/Stat3 pathway was preferentially active in CD44+CD24- breast cancer cells compared with other tumor cell types, and inhibition of JAK2 decreased their number and blocked growth of xenografts.
Journal ArticleDOI
Cell type-specific DNA methylation patterns in the human breast
Noga Bloushtain-Qimron,Noga Bloushtain-Qimron,Jun Yao,Eric L. Snyder,Michail Shipitsin,Lauren L. Campbell,Sendurai A. Mani,Min Hu,Haiyan Chen,Vadim Ustyansky,Jessica E. Antosiewicz,Pedram Argani,Marc K. Halushka,James A. Thomson,Paul D.P. Pharoah,Angel Porgador,Saraswati Sukumar,Ramon Parsons,Andrea L. Richardson,Martha R. Stampfer,Rebecca Gelman,Tatiana Nikolskaya,Yuri Nikolsky,Kornelia Polyak +23 more
TL;DR: The data suggest that epigenetically controlled transcription factors play a key role in regulating mammary epithelial cell phenotypes and imply similarities among epigenetic programs that define progenitor cell characteristics.
Journal ArticleDOI
A Putative Role for Psoriasin in Breast Tumor Progression
Ian E. Krop,Annette März,Hanna Carlsson,Xiaochun Li,Noga Bloushtain-Qimron,Min Hu,Rebecca Gelman,Michael S. Sabel,Stuart J. Schnitt,Sridhar Ramaswamy,Celina G. Kleer,Charlotta Enerbäck,Kornelia Polyak +12 more
TL;DR: Down-regulation of endogenous psoriasin expression via stable short hairpin RNAs in a human IBC cell line increases cell migration and invasion without influencing cell proliferation and survival in vitro but inhibits tumor growth in vivo.
Journal ArticleDOI
Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression
Celina G. Kleer,Noga Bloushtain-Qimron,Noga Bloushtain-Qimron,Yu-Hui Chen,Daniel R. Carrasco,Min Hu,Jun Yao,Stine Kathrein Kraeft,Laura C. Collins,Michael S. Sabel,Pedram Argani,Rebecca Gelman,Stuart J. Schnitt,Ian E. Krop,Kornelia Polyak +14 more
TL;DR: CTSK may function as a paracrine factor in breast tumorigenesis by promoting the invasiveness of tumor epithelial cells and this was blocked by CTSK inhibitors.