V
Vanessa Almendro
Researcher at Harvard University
Publications - 64
Citations - 7124
Vanessa Almendro is an academic researcher from Harvard University. The author has contributed to research in topics: Breast cancer & Skeletal muscle. The author has an hindex of 35, co-authored 63 publications receiving 6320 citations. Previous affiliations of Vanessa Almendro include Brigham and Women's Hospital & University of Barcelona.
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Journal ArticleDOI
Intra-tumour heterogeneity: a looking glass for cancer?
TL;DR: This Review discusses both genetic and non-genetic causes of phenotypic heterogeneity of tumour cells, with an emphasis on heritable phenotypes that serve as a substrate for clonal selection and the implications of intra-tumour heterogeneity in diagnostics and the development of therapeutic resistance.
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The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Lauren L. C. Marotta,Vanessa Almendro,Vanessa Almendro,Andriy Marusyk,Michail Shipitsin,Janina Schemme,Sarah R. Walker,Noga Bloushtain-Qimron,Jessica J. Kim,Sibgat Choudhury,Reo Maruyama,Zhenhua Wu,Mithat Gonen,Laura Mulvey,Marina Bessarabova,Sung Jin Huh,Serena J. Silver,So Young Kim,So Young Kim,So Yeon Park,Hee Eun Lee,Karen S. Anderson,Andrea L. Richardson,Tatiana Nikolskaya,Yuri Nikolsky,X. Shirley Liu,David E. Root,William C. Hahn,William C. Hahn,David A. Frank,Kornelia Polyak +30 more
TL;DR: The IL-6/JAK2/Stat3 pathway was preferentially active in CD44+CD24- breast cancer cells compared with other tumor cell types, and inhibition of JAK2 decreased their number and blocked growth of xenografts.
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Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
Andriy Marusyk,Andriy Marusyk,Doris P. Tabassum,Philipp M. Altrock,Vanessa Almendro,Vanessa Almendro,Franziska Michor,Kornelia Polyak +7 more
TL;DR: It is found that non-cell-autonomous driving of tumour growth, together with clonal interference, stabilizes sub-Clonal heterogeneity, thereby enabling inter-clonal interactions that can lead to new phenotypic traits.
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Cellular heterogeneity and molecular evolution in cancer.
TL;DR: Important considerations related to intratumor heterogeneity during tumor evolution are summarized and experimental approaches commonly used to infer intrumor heterogeneity are discussed and how these methodologies can be translated into clinical practice are described.
Journal ArticleDOI
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
Nasim Ahmadiyeh,Mark Pomerantz,Chiara Grisanzio,Paula Herman,Li Jia,Vanessa Almendro,Housheng Hansen He,Myles Brown,X. Shirley Liu,Matthew J. Davis,Jennifer L. Caswell,Christine A. Beckwith,Adam Hills,Laura E. MacConaill,Gerhard A. Coetzee,Meredith M. Regan,Matthew L. Freedman +16 more
TL;DR: Data is presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific.