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Serena J. Silver
Researcher at Novartis
Publications - 37
Citations - 12504
Serena J. Silver is an academic researcher from Novartis. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 25, co-authored 37 publications receiving 9788 citations. Previous affiliations of Serena J. Silver include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
David A. Barbie,Pablo Tamayo,Jesse S. Boehm,So Young Kim,Susan Moody,Ian F. Dunn,Anna C. Schinzel,Peter Sandy,Etienne Meylan,Claudia Scholl,Stefan Fröhling,Edmond M. Chan,Martin L. Sos,Kathrin Michel,Craig H. Mermel,Serena J. Silver,Barbara A. Weir,Jan H. Reiling,Qing Sheng,Piyush Gupta,Raymond C. Wadlow,Raymond C. Wadlow,Hanh Le,Sebastian Hoersch,Ben S. Wittner,Ben S. Wittner,Sridhar Ramaswamy,Sridhar Ramaswamy,David M. Livingston,David M. Sabatini,Matthew Meyerson,Matthew Meyerson,Roman K. Thomas,Eric S. Lander,Jill P. Mesirov,David E. Root,D. Gary Gilliland,Tyler Jacks,William C. Hahn +38 more
TL;DR: Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer.
Journal ArticleDOI
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Sarah A. Johnson,Nicholas J. Lyons,Alice H. Berger,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,David Y. Takeda,Roger Hu,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Peyton Greenside,Nathanael S. Gray,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +64 more
TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Lauren L. C. Marotta,Vanessa Almendro,Vanessa Almendro,Andriy Marusyk,Michail Shipitsin,Janina Schemme,Sarah R. Walker,Noga Bloushtain-Qimron,Jessica J. Kim,Sibgat Choudhury,Reo Maruyama,Zhenhua Wu,Mithat Gonen,Laura Mulvey,Marina Bessarabova,Sung Jin Huh,Serena J. Silver,So Young Kim,So Young Kim,So Yeon Park,Hee Eun Lee,Karen S. Anderson,Andrea L. Richardson,Tatiana Nikolskaya,Yuri Nikolsky,X. Shirley Liu,David E. Root,William C. Hahn,William C. Hahn,David A. Frank,Kornelia Polyak +30 more
TL;DR: The IL-6/JAK2/Stat3 pathway was preferentially active in CD44+CD24- breast cancer cells compared with other tumor cell types, and inhibition of JAK2 decreased their number and blocked growth of xenografts.
Journal ArticleDOI
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Ron Firestein,Adam J. Bass,So Young Kim,Ian F. Dunn,Serena J. Silver,Isil Guney,Isil Guney,Ellen Freed,Azra H. Ligon,Natalie Vena,Shuji Ogino,Milan G. Chheda,Milan G. Chheda,Pablo Tamayo,Stephen P. Finn,Yashaswi Shrestha,Yashaswi Shrestha,Jesse S. Boehm,Supriya Rani Jain,Emeric Bojarski,Craig H. Mermel,Craig H. Mermel,Jordi Barretina,Jordi Barretina,Jennifer Ang Chan,José Baselga,Josep Tabernero,David E. Root,Charles S. Fuchs,Massimo Loda,Ramesh A. Shivdasani,Matthew Meyerson,William C. Hahn +32 more
TL;DR: It is shown that the suppression of CDK8 expression inhibits proliferation in colon cancer cells characterized by high levels ofCDK8 and β-catenin hyperactivity, suggesting that therapeutic interventions targeting CDK 8 may confer a clinical benefit in β-Catenin-driven malignancies.
Journal ArticleDOI
A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection
Sagi Shapira,Sagi Shapira,Irit Gat-Viks,Bennett O.V. Shum,Amélie Dricot,Marciela M. de Grace,Marciela M. de Grace,Liguo Wu,Liguo Wu,Piyush Gupta,Tong Hao,Serena J. Silver,David E. Root,David E. Hill,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +17 more
TL;DR: A combination of yeast two-hybrid analysis and genome-wide expression profiling implicated hundreds of human factors in mediating viral-host interactions and pointed to potential roles for some unanticipated host and viral proteins in viral infection and the host response.