N
Norihito Kuno
Researcher at University of Texas MD Anderson Cancer Center
Publications - 3
Citations - 225
Norihito Kuno is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Nanoprobe & Preclinical imaging. The author has an hindex of 3, co-authored 3 publications receiving 220 citations.
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Journal ArticleDOI
Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe.
Parmeswaran Diagaradjane,Jacobo M. Orenstein-Cardona,Norman E. Colón-Casasnovas,Amit Deorukhkar,Shujun Shentu,Norihito Kuno,David L. Schwartz,Juri G. Gelovani,Sunil Krishnan +8 more
TL;DR: The measurable contrast enhancement of tumors 4 h after systemic administration of EGF-QD and its subsequent normalization at 24 h imply that this nanoprobe may permit quantifiable and repetitive imaging of EGFR expression.
Journal ArticleDOI
HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance
David L. Schwartz,James A. Bankson,Luc Bidaut,Yi He,Ryan R. Williams,Robert Lemos,Arun Kumar Thitai,Junghwan Oh,Andrei Volgin,Suren Soghomonyan,Hsin Hsien Yeh,Ryuichi Nishii,Uday Mukhopadhay,Mian M. Alauddin,Ioseb Mushkudiani,Norihito Kuno,Sunil Krishnan,William G. Bornman,Stephen Y. Lai,Garth Powis,John D. Hazle,Juri G. Gelovani +21 more
TL;DR: The results illustrate that tumor radioresistance is mediated by a capacity to compensate for stromal vascular disruption through HIF-1–dependent proangiogenic signaling and that clinically relevant vascular imaging techniques can spatially define mechanisms associated with tumor irradiation.
Proceedings ArticleDOI
EGF-conjugated Near-infrared quantum dots as nanoprobes for in-vivo imaging of EGFR expression
Parmeswaran Diagaradjane,Jacobo M. Orenstein-Cardona,Norman E. Colón-Casasnovas,Amit Deorukhkar,Shujun Shentu,Norihito Kuno,David L. Schwartz,Juri G. Gelovani,Sunil Krishnan +8 more
TL;DR: The ability to discriminate EGFR-overexpressing tumors from surrounding normal tissues using low concentration (10-pmol) of EGF-QD nanoprobe underscores the clinical relevance of this probe to evaluate therapeutic intervention.