Ryan R. Williams

TL;DR: It is concluded that PX-478 inhibits Hif-1α at multiple levels that together or individually may contribute to its antitumor activity against HIF-1 α-expressing tumors.

TL;DR: It is shown that PX-478 prevents postradiation HIF-1 signaling and abrogates downstream stromal adaptation in C6 and HN5 reporter xenografts as measured by serial ultrasound, vascular magnetic resonance imaging, and hypoxia response element–specific micro–positron emission tomography imaging.

TL;DR: It is demonstrated that the PX-478, HIF-1&agr; inhibitor, had significant antitumor activity against two orthotopic models of lung adenocarcinomas and two models of SCLC.

TL;DR: In conclusion, IL‐24 is expressed during wound repair and inhibits TGFα ‐induced migration and proliferation of keratinocytes in mice and successfully reprograms these cells for wound repair.

TL;DR: Thioredoxin-interacting protein, a putative tumor suppressor gene, is induced in response to hypoxia in a HIF-1&agr;-dependent manner in pancreatic cancer cells, resulting in increased apoptosis and increased sensitivity to platinum anticancer therapy.