B
Berhan Mandefro
Researcher at Cedars-Sinai Medical Center
Publications - 25
Citations - 1414
Berhan Mandefro is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 14, co-authored 21 publications receiving 1117 citations. Previous affiliations of Berhan Mandefro include International Practical Shooting Confederation.
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Journal ArticleDOI
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Alexandra B Keenan,Sherry L. Jenkins,Kathleen M. Jagodnik,Simon Koplev,Edward He,Denis Torre,Zichen Wang,Anders B. Dohlman,Moshe C. Silverstein,Alexander Lachmann,Maxim V. Kuleshov,Avi Ma'ayan,Vasileios Stathias,Raymond Terryn,Daniel J. Cooper,Michele Forlin,Amar Koleti,Dusica Vidovic,Caty Chung,Stephan C. Schürer,Jouzas Vasiliauskas,Marcin Pilarczyk,Behrouz Shamsaei,Mehdi Fazel,Yan Ren,Wen Niu,Nicholas A. Clark,Shana White,Naim Al Mahi,Lixia Zhang,Michal Kouril,John F. Reichard,Siva Sivaganesan,Mario Medvedovic,Jaroslaw Meller,Rick J. Koch,Marc R. Birtwistle,Ravi Iyengar,Eric A. Sobie,Evren U. Azeloglu,Julia A. Kaye,Jeannette Osterloh,Kelly Haston,Jaslin Kalra,Steve Finkbiener,Jonathan Z. Li,Pamela Milani,Miriam Adam,Renan Escalante-Chong,Karen Sachs,Alexander LeNail,Divya Ramamoorthy,Ernest Fraenkel,Gavin Daigle,Uzma Hussain,Alyssa Coye,Jeffrey D. Rothstein,Dhruv Sareen,Loren Ornelas,Maria G. Banuelos,Berhan Mandefro,Ritchie Ho,Clive N. Svendsen,Ryan G. Lim,Jennifer Stocksdale,Malcolm Casale,Terri G. Thompson,Jie Wu,Leslie M. Thompson,Victoria Dardov,Vidya Venkatraman,Andrea Matlock,Jennifer E. Van Eyk,Jacob D. Jaffe,Malvina Papanastasiou,Aravind Subramanian,Todd R. Golub,Sean D. Erickson,Mohammad Fallahi-Sichani,Marc Hafner,Nathanael S. Gray,Jia-Ren Lin,Caitlin E. Mills,Jeremy L. Muhlich,Mario Niepel,Caroline E. Shamu,Elizabeth H. Williams,David Wrobel,Peter K. Sorger,Laura M. Heiser,Joe W. Gray,James E. Korkola,Gordon B. Mills,Mark A. LaBarge,Mark A. LaBarge,Heidi S. Feiler,Mark A. Dane,Elmar Bucher,Michel Nederlof,Damir Sudar,Sean M. Gross,David Kilburn,Rebecca Smith,Kaylyn Devlin,Ron Margolis,Leslie Derr,Albert Lee,Ajay Pillai +107 more
TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.
Journal ArticleDOI
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Ryan G. Lim,Lisa Salazar,D Wilton,Alvin R. King,Jennifer Stocksdale,Delaram Sharifabad,Alice L Lau,Beth Stevens,Jack C. Reidling,Sara T. Winokur,Malcolm Casale,Leslie M. Thompson,Mónica Pardo,A Gerardo García Díaz-Barriga,Marco Straccia,Phil Sanders,Jordi Alberch,Josep M. Canals,Julia A. Kaye,Mariah Dunlap,Lisa Jo,Hanna May,Elliot Mount,Cliff Anderson-Bergman,Kelly Haston,Steven Finkbeiner,Amanda J. Kedaigle,Theresa A. Gipson,Ferah Yildirim,Christopher W. Ng,Pamela Milani,David E. Housman,Ernest Fraenkel,Nicholas D. Allen,Paul J. Kemp,Ranjit Singh Atwal,Marta Biagioli,James F. Gusella,Marcy E. MacDonald,Sergey S Akimov,Nicolas Arbez,Jacqueline Stewart,Christopher A. Ross,Virginia B. Mattis,Colton M Tom,Loren Ornelas,Anais Sahabian,Lindsay Lenaeus,Berhan Mandefro,Dhruv Sareen,Clive N. Svendsen +50 more
TL;DR: The data suggest that mutant huntingtin impairs neurodevelopmental pathways that could disrupt synaptic homeostasis and increase vulnerability to the pathologic consequence of expanded polyglutamine repeat-associated phenotypes in neural cells and of cognitive impairment and synaptic pathology in HD model R6/2 mice.
Journal ArticleDOI
Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells
Uri Ben-David,Gal Arad,Uri Weissbein,Berhan Mandefro,Adva Maimon,Tamar Golan-Lev,Kavita Narwani,Amander T. Clark,Peter W. Andrews,Nissim Benvenisty,Juan Carlos Biancotti +10 more
TL;DR: Comparison of proliferation, differentiation and apoptosis between diploid and aneuploid hPSC shows that trisomy 12 significantly increases the proliferation rate of hPSCs, mainly as a consequence of increased replication.
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Ryan G. Lim,Lisa Salazar,D Wilton,Alvin R. King,Jennifer Stocksdale,Delaram Sharifabad,L Alice Lau,Beth Stevens,Jack C. Reidling,Sara T. Winokur,Malcolm Casale,Leslie M. Thompson,Mónica Pardo,A Gerardo García Díaz-Barriga,Marco Straccia,Phil Sanders,Jordi Alberch,Josep M. Canals,Julia A. Kaye,Mariah Dunlap,Lisa Jo,Hanna May,Elliot Mount,Cliff Anderson-Bergman,Kelly Haston,Steven Finkbeiner,Nicholas D. Allen,Paul J. Kemp,Ranjit Singh Atwal,Marta Biagioli,James F. Gusella,Marcy E. MacDonald,Sergey S Akimov,Nicolas Arbez,Jacqueline Stewart,Christopher A. Ross,Virginia B. Mattis,Colton M Tom,Loren Ornelas,Anais Sahabian,Lindsay Lenaeus,Berhan Mandefro,Dhruv Sareen,Clive N. Svendsen,Amanda J. Kedaigle,Theresa Anne Wasylenko,Ferah Yildirim,Christopher W. Ng,Pamela Milani,David E. Housman,Ernest Fraenkel +50 more
Journal ArticleDOI
Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development
Samuel Sances,Ritchie Ho,Gad D. Vatine,Dylan West,Alex Laperle,Amanda Meyer,Marlesa Godoy,Paul S. Kay,Berhan Mandefro,Seigo Hatata,Chris Hinojosa,Norman Wen,Dhruv Sareen,Geraldine A. Hamilton,Clive N. Svendsen +14 more
TL;DR: The results show that the vascular system has specific maturation effects on spinal cord neural tissue, and the use of Organ-Chips can move stem cell models closer to an in vivo condition.