N
Nu Zhang
Researcher at Sun Yat-sen University
Publications - 98
Citations - 5330
Nu Zhang is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 25, co-authored 68 publications receiving 3699 citations. Previous affiliations of Nu Zhang include University of Texas MD Anderson Cancer Center & Wenzhou Medical College.
Papers
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Journal ArticleDOI
Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis
Yibing Yang,Xinya Gao,Maolei Zhang,Sheng Yan,Chengjun Sun,Feizhe Xiao,Nunu Huang,Xuesong Yang,Kun Zhao,Huangkai Zhou,Suyun Huang,Bo Xie,Nu Zhang +12 more
TL;DR: Endogenous circRNA encodes a functional protein in human cells, and circ-FBXW7 and FBXW 7-185aa have potential prognostic implications in brain cancer.
Journal ArticleDOI
FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis
Nu Zhang,Nu Zhang,Ping Wei,Ping Wei,Aihua Gong,Wen Tai Chiu,Hsueh Te Lee,Howard Colman,He Huang,Jianfei Xue,Mingguang Liu,Yong Wang,Raymond Sawaya,Keping Xie,Keping Xie,W. K. Alfred Yung,René H. Medema,Xi He,Suyun Huang,Suyun Huang +19 more
TL;DR: FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells, and Wnt3a increases the level and nuclear translocation of FoxM1, which binds directly to β- catenin and enhances β-Catenin nuclear localization and transcriptional activity.
Journal ArticleDOI
A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.
Maolei Zhang,Nunu Huang,Xuesong Yang,Jingyan Luo,Sheng Yan,Feizhe Xiao,Wenping Chen,Xinya Gao,Kun Zhao,Huangkai Zhou,Ziqiang Li,Liu Ming,Bo Xie,Nu Zhang +13 more
TL;DR: It is shown that a circRNA containing an open reading frame (ORF) driven by the internal ribosome entry site (IRES) can translate a functional protein, which is generated from overlapping genetic codes of circ-SHPRH and is a tumor suppressor in human glioblastoma.
Journal ArticleDOI
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
Maolei Zhang,Kun Zhao,Xiaoping Xu,Yibing Yang,Sheng Yan,Sheng Yan,Ping Wei,Hui Liu,Jianbo Xu,Feizhe Xiao,Huangkai Zhou,Xuesong Yang,Nunu Huang,Jinglei Liu,Kejun He,Keping Xie,Gong Zhang,Suyun Huang,Nu Zhang +18 more
TL;DR: A 87-amino-acid peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) is identified that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes.
Journal ArticleDOI
Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival.
Jun Li,Nu Zhang,Li Bing Song,Wen Ting Liao,Lili Jiang,Lili Jiang,Li-Yun Gong,Li-Yun Gong,Jueheng Wu,Jueheng Wu,Jie Yuan,Hui Zhong Zhang,Mu Sheng Zeng,Mengfeng Li,Mengfeng Li +14 more
TL;DR: The results suggest that AEG-1 protein is a valuable marker of breast cancer progression, and high A EG-1 expression is associated with poor overall survival in patients with breast cancer.