Nurten Yigit

TL;DR: This work developed a novel single cell strand-specific total RNA library preparation method addressing all the shortcomings of existing methods and demonstrating that the method detects an equal or higher number of genes compared to classic polyA[+] RNA-seq, including novel and non-polyadenylated genes.

TL;DR: Two complementary approaches for targeted depletion of 5′ tRNA halves in murine serum samples and when comparing miRNA levels in tumor-carrying versus tumor-free mice are evaluated, resulting in a 6-fold increase of mapped miRNA reads and 60% more unique miRNAs detected.

TL;DR: The MISpheroID Consortium as discussed by the authors developed a crowdsourcing knowledgebase that assembles the experimental parameters of 3,058 published spheroid-related experiments to facilitate interpretation, stimulate transparency and increase awareness.

TL;DR: The venetoclax/idasanutlin combination was consistently found to be highly synergistic in a diverse panel of neuroblastoma cell lines, including cells with high MCL1 expression levels and a more pronounced induction of apoptosis was found to underlie the synergistic interaction.

TL;DR: This work develops a novel single cell strand-specific total RNA library preparation method addressing all the shortcomings of existing methods and demonstrates that this method detects an equal or higher number of genes compared to classic polyA[+] RNA-seq, including novel and non-polyadenylated genes.