N
Nyoun Soo Kwon
Researcher at Chung-Ang University
Publications - 83
Citations - 5252
Nyoun Soo Kwon is an academic researcher from Chung-Ang University. The author has contributed to research in topics: Tyrosinase & Microphthalmia-associated transcription factor. The author has an hindex of 25, co-authored 83 publications receiving 5090 citations. Previous affiliations of Nyoun Soo Kwon include Cleveland Clinic & Cornell University.
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Journal ArticleDOI
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein
TL;DR: Gel filtration chromatography indicated that the induced NO synthase was catalytically competent as a dimer of approximately 250 kDa but could be dissociated into inactive monomers of approximately 130 kDa in the absence of L-arginine, FAD, and tetrahydrobiopterin.
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N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
Dennis J. Stuehr,Nyoun Soo Kwon,Carl Nathan,Owen W. Griffith,Paul L. Feldman,Jeffrey Wiseman +5 more
TL;DR: Results support a mechanism in which N omega-hydroxy-L-arginine is generated as an intermediate in nitric oxide (.NO) synthesis through an NADPH-dependent hydroxylation of L-argInine.
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Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages
TL;DR: The major active component in LF was dialyzable, water soluble, and cationic at acidic to neutral pH, and was facilitated by catalytic amounts of H4biopterin.
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Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.
Dennis J. Stuehr,Olufunmilayo A. Fasehun,Nyoun Soo Kwon,Steven S. Gross,Jose A. Gonzalez,Roberto Levi,Carl Nathan +6 more
TL;DR: The results suggest that NO∗ synthesis in both macrophages and endothelial cells depends on an NADPH‐utilizing flavoprotein, and DPI and its analogs are likely to prove useful in analyzing the physiologic and pathophysiologic roles of NO·.
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Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.
TL;DR: No gas and lysates of activated macrophages that generated comparable amounts of NO led to the same degree of inhibition of partially purified RR from L1210 mouse lymphoma cells, suggesting that cytostasis by activated Macrophages and by hydroxyurea has comparable mechanisms, including, but probably not limited to, inhibition of RR.