O
O. K. Nepryakhina
Researcher at Moscow State University
Publications - 5
Citations - 475
O. K. Nepryakhina is an academic researcher from Moscow State University. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 3, co-authored 5 publications receiving 424 citations.
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Journal ArticleDOI
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies
Yuri N. Antonenko,A. V. Avetisyan,Lora E. Bakeeva,Boris V. Chernyak,Vyacheslav A. Chertkov,Lidia V. Domnina,O. Yu. Ivanova,D. S. Izyumov,Khailova Ls,S.S. Klishin,Galina A. Korshunova,Konstantin G. Lyamzaev,Maria S. Muntyan,O. K. Nepryakhina,A. A. Pashkovskaya,O. Yu. Pletjushkina,Antonina V. Pustovidko,Vitaly A. Roginsky,Tatyana I. Rokitskaya,Enno K. Ruuge,V. B. Saprunova,Inna I. Severina,Ruben A. Simonyan,I. V. Skulachev,Maxim V. Skulachev,Natalia V. Sumbatyan,I. V. Sviryaeva,Vadim N. Tashlitsky,J. M. Vassiliev,M. Yu. Vyssokikh,Lev S. Yaguzhinsky,Andrey A. Zamyatnin,Vladimir P. Skulachev +32 more
TL;DR: It is concluded that SkQs are rechargeable, mitochondria-targeted antioxidants of very high efficiency and specificity and might be used to effectively prevent ROS-induced oxidation of lipids and proteins in the inner mitochondrial membrane in vivo.
Journal ArticleDOI
Effect of oxidative stress on dynamics of mitochondrial reticulum
O. Yu. Pletjushkina,Konstantin G. Lyamzaev,E. N. Popova,O. K. Nepryakhina,O. Yu. Ivanova,Lidia V. Domnina,Boris V. Chernyak,Vladimir P. Skulachev +7 more
TL;DR: It is shown that inhibitors of the respiratory chain cause fission of mitochondria in HeLa cells and fibroblasts, whereas a mitochondria-targeted antioxidant (MitoQ) inhibits this effect.
Journal ArticleDOI
Mitochondria as source of reactive oxygen species under oxidative stress. Study with novel mitochondria-targeted antioxidants — the “Skulachev-ion” derivatives
D. S. Izyumov,Lidia V. Domnina,O. K. Nepryakhina,A. V. Avetisyan,S. A. Golyshev,O. Y. Ivanova,M. V. Korotetskaya,Konstantin G. Lyamzaev,Olga Yu. Pletjushkina,E. N. Popova,Boris V. Chernyak +10 more
TL;DR: It was shown that mitochondria-targeted antioxidants at nanomolar concentrations rapidly and selectively accumulated in mitochondria and prevented oxidation of mitochondrial components under oxidative stress induced by hydrogen peroxide, and the possible role of the small fraction of “bad” mitochondria in cell physiology is discussed.
Mitochondria-targeted cationic plastoquinone derivatives: Synthesis and in vitro studies
Y.N. Antonenko,A.V. Avetisyan,L.E. Bakeeva,B.V. Chernyak,Vyacheslav A. Chertkov,Lidia V. Domnina,O. Y. Ivanova,D. S. Izyumov,Lyudmila S. Khailova,S.S. Klishin,Galina A. Korshunova,K.G. Lyamzaev,Muntyan,O. K. Nepryakhina,A.A. Pashkovskaya,O.Y. Pletjushkina,Antonina V. Pustovidko,Vitaly A. Roginsky,T.I. Rokitskaya,E.K. Ruuge,V.B. Saprunova,I.I. Severina,R.A. Simonyan,I. V. Skulachev,Maxim V. Skulachev,N.V. Sumbatyan,I.V. Sviryaeva,Vadim N. Tashlitsky,J. M. Vassiliev,Mikhail Yu. Vyssokikh,L.S. Yaguzhinsky,Andrey A. Zamyatnin,V.P. Skulachev +32 more
Journal ArticleDOI
Reactive oxygen species generated in mitochondria induce fragmentation of the mitochondrial reticulum in HeLa cells
O. K. Nepryakhina,A. Yu. Kuznetsova,Konstantin G. Lyamzaev,D. S. Izyumov,O. Yu. Pletjushkina,Boris V. Chernyak,Vladimir P. Skulachev +6 more
TL;DR: The pathway of signal transmission from various stimuli that induce oxidative stress or apoptosis to the machinery of mitochondrial fission is of interest and the central role in this pathway may be played by reactive oxygen species (ROSs), because their content increases during oxidative stress and apoptosis.