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Natalia V. Sumbatyan
Researcher at Moscow State University
Publications - 44
Citations - 1503
Natalia V. Sumbatyan is an academic researcher from Moscow State University. The author has contributed to research in topics: Peptide & Ribosome. The author has an hindex of 14, co-authored 41 publications receiving 1334 citations. Previous affiliations of Natalia V. Sumbatyan include Institut Gustave Roussy & South Ural State University.
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Journal ArticleDOI
Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties
Galina F. Sud'ina,O. K. Mirzoeva,Marina A. Pushkareva,Galina A. Korshunova,Natalia V. Sumbatyan,Sergei D. Varfolomeev +5 more
TL;DR: Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5‐lipoxygenase in the micromolar concentration range and exhibits antioxidant properties.
Journal ArticleDOI
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies
Yuri N. Antonenko,A. V. Avetisyan,Lora E. Bakeeva,Boris V. Chernyak,Vyacheslav A. Chertkov,Lidia V. Domnina,O. Yu. Ivanova,D. S. Izyumov,Khailova Ls,S.S. Klishin,Galina A. Korshunova,Konstantin G. Lyamzaev,Maria S. Muntyan,O. K. Nepryakhina,A. A. Pashkovskaya,O. Yu. Pletjushkina,Antonina V. Pustovidko,Vitaly A. Roginsky,Tatyana I. Rokitskaya,Enno K. Ruuge,V. B. Saprunova,Inna I. Severina,Ruben A. Simonyan,I. V. Skulachev,Maxim V. Skulachev,Natalia V. Sumbatyan,I. V. Sviryaeva,Vadim N. Tashlitsky,J. M. Vassiliev,M. Yu. Vyssokikh,Lev S. Yaguzhinsky,Andrey A. Zamyatnin,Vladimir P. Skulachev +32 more
TL;DR: It is concluded that SkQs are rechargeable, mitochondria-targeted antioxidants of very high efficiency and specificity and might be used to effectively prevent ROS-induced oxidation of lipids and proteins in the inner mitochondrial membrane in vivo.
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Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs).
Vladimir P. Skulachev,Yury N. Antonenko,Dmitry A. Cherepanov,Boris V. Chernyak,D. S. Izyumov,Ludmila S. Khailova,S.S. Klishin,Galina A. Korshunova,Konstantin G. Lyamzaev,Olga Yu. Pletjushkina,Vitaly A. Roginsky,Tatiana I. Rokitskaya,Fedor F. Severin,Inna I. Severina,Ruben A. Simonyan,Maxim V. Skulachev,Natalia V. Sumbatyan,E. I. Sukhanova,Vadim N. Tashlitsky,T. A. Trendeleva,Mikhail Yu. Vyssokikh,Renata A. Zvyagilskaya +21 more
TL;DR: In mitochondria, the cycling gives rise to mild uncoupling, thereby decreasing membrane potential and ROS generation coupled to reverse electron transport in the respiratory chain and in yeast cells, dodecyltriphenylphosphonium (capital ES, Cyrillic12TPP), the cationic part of SkQ1, induces uncoupled that is mitochondria-targeted.
Journal ArticleDOI
Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition
Agata L. Starosta,Agata L. Starosta,Viktoriya V. Karpenko,A. V. Shishkina,Aleksandra Mikolajka,Aleksandra Mikolajka,Natalia V. Sumbatyan,Frank Schluenzen,Galina A. Korshunova,Alexey A. Bogdanov,Daniel N. Wilson,Daniel N. Wilson +11 more
TL;DR: Surprisingly, it is found that macrolide antibiotics do not inhibit translation of all nascent chains similarly, but rather exhibit polypeptide-specific inhibitory effects, providing a change to the general mechanistic understanding of macrolides inhibition.
Journal ArticleDOI
Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers
Yuri N. Antonenko,A. V. Avetisyan,Dmitry A. Cherepanov,Dmitry A. Knorre,Galina A. Korshunova,Olga V. Markova,Silvia M. Ojovan,Irina V. Perevoshchikova,Antonina V. Pustovidko,Tatyana I. Rokitskaya,Inna I. Severina,Ruben A. Simonyan,Ekaterina A. Smirnova,Alexander A. Sobko,Natalia V. Sumbatyan,Fedor F. Severin,Vladimir P. Skulachev +16 more
TL;DR: Together, the data suggest that rhodamine 19-based cationic protonophores are self-limiting; their uncoupling activity is maximal at high membrane potential, but the activity decreases membrane potentials, which causes partial efflux of the uncouplers from mitochondria and, hence, prevents further membrane potential decrease.