O
Olaf Wilhelm
Researcher at Ludwig Maximilian University of Munich
Publications - 74
Citations - 2535
Olaf Wilhelm is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Urokinase receptor & Plasminogen activator. The author has an hindex of 25, co-authored 74 publications receiving 2478 citations. Previous affiliations of Olaf Wilhelm include Technische Universität München.
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Journal ArticleDOI
Clinical impact of the plasminogen activation system in tumor invasion and metastasis : Prognostic relevance and target for therapy
Manfred Schmitt,Nadia Harbeck,C Thomssen,Olaf Wilhelm,Viktor Magdolen,Ute Reuning,Kurt Ulm,Heinz Höfler,Fritz Jänicke,Henner Graeff +9 more
TL;DR: The strong correlation between elevated uPA and/or PAI-1 values in primary cancer tissues and the tumor invasion/ metastasis capacity of cancer cells, proteolytic factors have been selected as targets for therapy.
Journal ArticleDOI
The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells
TL;DR: The interaction of VN with the u-PA receptor may be involved in the regulation of cellular processes necessary for endothelial cell invasion and migration at VN-rich extracellular matrix sites.
Journal ArticleDOI
Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).
TL;DR: Besides its proteolytic activity, uPA in concert with uPAR exert biological effects characteristic for molecules with signal transducing properties including chemotaxis, migration/invasion, adhesion, and mitogenesis.
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Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression.
Olaf Wilhelm,Sabine Wilhelm,Gemma M. Escott,Verena Lutz,Viktor Magdolen,Manfred Schmitt,Daniel B. Rifkin,E. Lynette Wilson,Henner Graeff,Georg Brunner,Georg Brunner +10 more
TL;DR: The data suggest that cellular G PI‐PLD might be involved in the generation of circulating prognostic markers in cancer and possibly regulate the function of GPI‐anchored proteins by generating functionally distinct, soluble counterparts.
Journal ArticleDOI
The urokinase plasminogen activator system as a novel target for tumour therapy
Manfred Schmitt,Olaf Wilhelm,Ute Reuning,Achim Krüger,Nadia Harbeck,Ernst Lengyel,Henner Graeff,Bernd Gansbacher,Horst Kessler,Markus Bürgle,Jörg Stürzebecher,Stefan Sperl,Viktor Magdolen +12 more
TL;DR: There is substantial hope that substances designed to affect or turn off the plasminogen activation system will eventually be administered to cancer patients thereby opening a new vista for tumour biology-based, individualized cancer therapy.