O
Olav L. M. Bijvoet
Researcher at Leiden University
Publications - 39
Citations - 2599
Olav L. M. Bijvoet is an academic researcher from Leiden University. The author has contributed to research in topics: Bisphosphonate & Bone resorption. The author has an hindex of 27, co-authored 39 publications receiving 2559 citations.
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Journal ArticleDOI
Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis.
Clemens W.G.M. Löwik,G. van der Pluijm,Henny Bloys,Klaas Hoekman,Olav L. M. Bijvoet,L.A. Aarden,Socrates E. Papapoulos +6 more
TL;DR: It is suggested that IL-6 produced by osteogenic cells may be a mediator in PTH-stimulated osteoclastic bone resorption and this action is exerted probably through an effect on the formation of osteoclasts (osteoclastogenesis) rather than on the activation of already existing mature osteoclabs.
Journal ArticleDOI
Palliative pamidronate treatment in patients with bone metastases from breast cancer.
A.T.M. van Holten-Verzantvoort,H.M. Kroon,Olav L. M. Bijvoet,F.J. Cleton,L.V.A.M. Beex,G. Blijham,Jo Hermans,J.P. Neijt,Socrates E. Papapoulos,Harm Sleeboom +9 more
TL;DR: Pamidronate treatment of breast cancer patients efficaciously reduced skeletal morbidity and the effect appeared to be dose-dependent.
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Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: The effect of a bisphosphonate
Clemens W.G.M. Löwik,G. van der Pluijm,L. van der Wee-Pals,H. Bloys van Treslong-de Groot,Olav L. M. Bijvoet +4 more
TL;DR: It is suggested that the bisphosphonate interferes with a matrix factor that is essential for the attachment and subsequent transformation of the osteoclast precursor into the mature phenotype.
Journal ArticleDOI
Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats.
TL;DR: It is concluded that the lower doses of APD inhibited resorption of bone and cartilage, possibly by physicochemical stabilization of bone mineral, whereas the effect on bone apposition was due to a cellular homeostatic mechanism.
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Crystal agglomeration is a major element in calcium oxalate urinary stone formation
TL;DR: The effects of urines from 36 healthy subjects and 86 calcium oxalate renal stone formers on calciumOxalate monohydrate crystallization kinetics were studied using a seeded crystal growth method, finding the urines of healthy subjects were found to increase the solubility and to strongly inhibit the growth and the agglomeration of calcium Oxalate Monohydrate crystals.