S
Socrates E. Papapoulos
Researcher at Leiden University Medical Center
Publications - 308
Citations - 24605
Socrates E. Papapoulos is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Osteoporosis & Bone remodeling. The author has an hindex of 79, co-authored 306 publications receiving 23202 citations. Previous affiliations of Socrates E. Papapoulos include Leiden University.
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Journal ArticleDOI
Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research
Elizabeth Shane,David B. Burr,Peter R. Ebeling,Bo Abrahamsen,Robert A. Adler,Thomas D. Brown,Angela M. Cheung,Felicia Cosman,Jeffrey R. Curtis,Richard M. Dell,David W. Dempster,Thomas A. Einhorn,Harry K. Genant,Piet Geusens,Klaus Klaushofer,Kenneth J. Koval,Joseph M. Lane,Fergus McKiernan,Ross E. McKinney,Alvin Choong Meng Ng,Jeri W. Nieves,Regis J. O'Keefe,Socrates E. Papapoulos,Howe Tet Sen,Marjolein C. H. van der Meulen,Robert S. Weinstein,Michael P. Whyte +26 more
TL;DR: This newer evidence suggests that AFFs are stress or insufficiency fractures, and studies with radiographic review consistently report significant associations between A FFs and BP use, although the strength and magnitude of effect vary.
MonographDOI
Primer on the metabolic bone diseases and disorders of mineral metabolism
John P. Bilezikian,Roger Bouillon,Thomas L. Clemens,Juliet E. Compston,Douglas C. Bauer,Peter R. Ebeling,Klaus Engelke,David Goltzman,Theresa A. Guise,Suzanne M. Jan de Beur,Harald Jüppner,Karen M. Lyons,Laurie K. McCauley,Michael R. McClung,Paul D. Miller,Socrates E. Papapoulos,G. David Roodman,Clifford J. Rosen,Ego Seeman,Ego Seeman,Rajesh V. Thakker,Michael P. Whyte,Michael P. Whyte,Mone Zaidi +23 more
TL;DR: This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats.
Journal ArticleDOI
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
Kenneth E. S. Poole,Rutger L. van Bezooijen,Nigel Loveridge,Herman Hamersma,Socrates E. Papapoulos,Clemens W.G.M. Löwik,Jonathan Reeve +6 more
TL;DR: In vivo evidence is provided for the first time to support the concept that osteocytes secrete sclerostin after they become embedded in a mineralized matrix to limit further bone formation by osteoblasts and propose that sclerOSTin production by osteocytes may regulate the linear extent of formation and the induction or maintenance of a lining cell phenotype on bone surfaces.
Journal ArticleDOI
Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
Rutger L. van Bezooijen,Bernard A.J. Roelen,Annemieke Visser,Lianne van der Wee-Pals,Edwin de Wilt,Marcel Karperien,Herman Hamersma,Socrates E. Papapoulos,Peter ten Dijke,Clemens W.G.M. Löwik +9 more
TL;DR: It is shown here that SOST/sclerostin is expressed exclusively by osteocytes in mouse and human bone and inhibits the differentiation and mineralization of murine preosteoblastic cells (KS483) and its unique localization and action on osteoblasts suggest that sclerost in may be the previously proposed osteocyte-derived factor that is transported to osteoblast at the bone surface and inhibits bone formation.
Journal ArticleDOI
Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A
Martine Deckers,Rutger L. van Bezooijen,Geertje van der Horst,Jakomijn Hoogendam,Chris van der Bent,Socrates E. Papapoulos,Clemens W.G.M. Löwik +6 more
TL;DR: This study investigated whether bone morphogenetic proteins (BMPs) stimulate osteoblastogenesis and angiogenesis through the production of VEGF-A, and used the murine preosteoblast-like cell line KS483, which forms mineralized nodules in vitro.