C
Clemens W.G.M. Löwik
Researcher at Leiden University Medical Center
Publications - 261
Citations - 22802
Clemens W.G.M. Löwik is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Bone resorption & Cancer. The author has an hindex of 77, co-authored 257 publications receiving 21446 citations. Previous affiliations of Clemens W.G.M. Löwik include Leiden University & Karolinska Institutet.
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Journal ArticleDOI
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
Kenneth E. S. Poole,Rutger L. van Bezooijen,Nigel Loveridge,Herman Hamersma,Socrates E. Papapoulos,Clemens W.G.M. Löwik,Jonathan Reeve +6 more
TL;DR: In vivo evidence is provided for the first time to support the concept that osteocytes secrete sclerostin after they become embedded in a mineralized matrix to limit further bone formation by osteoblasts and propose that sclerOSTin production by osteocytes may regulate the linear extent of formation and the induction or maintenance of a lining cell phenotype on bone surfaces.
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Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
Rutger L. van Bezooijen,Bernard A.J. Roelen,Annemieke Visser,Lianne van der Wee-Pals,Edwin de Wilt,Marcel Karperien,Herman Hamersma,Socrates E. Papapoulos,Peter ten Dijke,Clemens W.G.M. Löwik +9 more
TL;DR: It is shown here that SOST/sclerostin is expressed exclusively by osteocytes in mouse and human bone and inhibits the differentiation and mineralization of murine preosteoblastic cells (KS483) and its unique localization and action on osteoblasts suggest that sclerost in may be the previously proposed osteocyte-derived factor that is transported to osteoblast at the bone surface and inhibits bone formation.
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The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery
Boudewijn E. Schaafsma,J. Sven D. Mieog,Merlijn Hutteman,Joost R. van der Vorst,Peter J. K. Kuppen,Clemens W.G.M. Löwik,John V. Frangioni,Cornelis J.H. van de Velde,Alexander L. Vahrmeijer +8 more
TL;DR: Although non‐targeted and non‐conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence‐guided surgery, understanding its advantages and limitations is of significant importance.
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Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A
Martine Deckers,Rutger L. van Bezooijen,Geertje van der Horst,Jakomijn Hoogendam,Chris van der Bent,Socrates E. Papapoulos,Clemens W.G.M. Löwik +6 more
TL;DR: This study investigated whether bone morphogenetic proteins (BMPs) stimulate osteoblastogenesis and angiogenesis through the production of VEGF-A, and used the murine preosteoblast-like cell line KS483, which forms mineralized nodules in vitro.
Journal ArticleDOI
Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation.
Martine Deckers,Marcel Karperien,Chris van der Bent,Takeyoshi Yamashita,Socrates E. Papapoulos,Clemens W.G.M. Löwik +5 more
TL;DR: Examination of the expression of VEGF-A, -B, -C, and -D and their receptors in a model of osteoblast differentiation using the mouse preosteoblast-like cell line KS483 found that VEGf-A production during osteOBlast differentiation was stimulated by insulin-like...