O
Olena Pylypenko
Researcher at PSL Research University
Publications - 46
Citations - 2839
Olena Pylypenko is an academic researcher from PSL Research University. The author has contributed to research in topics: GTPase & Rab. The author has an hindex of 24, co-authored 46 publications receiving 2549 citations. Previous affiliations of Olena Pylypenko include Max Planck Society & Curie Institute.
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Journal ArticleDOI
Rab GTPases at a glance.
TL;DR: It has been two decades since the yeast Ypt1 and Sec4 proteins and the mammalian Rab (Ras-related proteins in brain) GTPases were first identified as evolutionarily conserved, essential regulators of membrane trafficking.
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KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron
Hélène Louis-Dit-Picard,Hélène Louis-Dit-Picard,Julien Barc,Julien Barc,Daniel Trujillano,Stéphanie Miserey-Lenkei,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Olena Pylypenko,Geneviève Beaurain,Geneviève Beaurain,Amélie Bonnefond,Amélie Bonnefond,Olivier Sand,Olivier Sand,Christophe Simian,Emmanuelle Vidal-Petiot,Emmanuelle Vidal-Petiot,Christelle Soukaseum,Christelle Soukaseum,Chantal Mandet,Chantal Mandet,Françoise Broux,Olivier Chabre,Michel Delahousse,Vincent L.M. Esnault,Béatrice Fiquet,Pascal Houillier,Pascal Houillier,Corinne Isnard Bagnis,Jens Koenig,Martin Konrad,Paul Landais,Paul Landais,Chebel Mourani,Patrick Niaudet,Patrick Niaudet,Vincent Probst,Christel Thauvin,Robert J. Unwin,Steven D. Soroka,Georg Ehret,Georg Ehret,Stephan Ossowski,Mark J. Caulfield,Patrick Bruneval,Patrick Bruneval,Xavier Estivill,Philippe Froguel,Philippe Froguel,Philippe Froguel,Juliette Hadchouel,Juliette Hadchouel,Jean-Jacques Schott,Xavier Jeunemaitre,Xavier Jeunemaitre +55 more
TL;DR: A role is established for KLHL3 as a new member of the complex signaling pathway regulating ion homeostasis in the distal nephron and indirectly blood pressure.
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Structure of Rab GDP-Dissociation Inhibitor in Complex with Prenylated YPT1 GTPase
Alexey Rak,Olena Pylypenko,Thomas Durek,Anja Watzke,Susanna Kushnir,Lucas Brunsveld,Herbert Waldmann,Roger S. Goody,Kirill Alexandrov +8 more
TL;DR: The structure of the monoprenylated Ypt1:RabGDI complex provides a structural basis for the ability of RabGDI to inhibit the release of nucleotide by Rab proteins and provides a molecular basis for understanding a RabG DI mutant that causes mental retardation in humans.
Journal ArticleDOI
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
TL;DR: In this article, the authors demonstrate that although Rab27A can be prenylated by REP-2, this reaction can be effectively inhibited by other Rab proteins, providing a possible explanation for the accumulation of unprenylated Rab 27A in choroideremia.
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The PX-BAR membrane-remodeling unit of sorting nexin 9
TL;DR: In this paper, crystal structures of the functional membrane-remodeling unit of SNX9 were reported and shown that it efficiently tubulates lipid membranes in vivo and in vitro.