P
Patrick Bruneval
Researcher at French Institute of Health and Medical Research
Publications - 444
Citations - 38244
Patrick Bruneval is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 82, co-authored 421 publications receiving 33414 citations. Previous affiliations of Patrick Bruneval include European University & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
TL;DR: In situ analysis of tumor-infiltrating immune cells may be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.
Journal ArticleDOI
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Gabriela Bindea,Bernhard Mlecnik,Bernhard Mlecnik,Bernhard Mlecnik,Marie Tosolini,Marie Tosolini,Marie Tosolini,Amos Kirilovsky,Amos Kirilovsky,Amos Kirilovsky,Maximilian J. Waldner,Anna C. Obenauf,Helen K. Angell,Helen K. Angell,Helen K. Angell,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Anne Berger,Patrick Bruneval,Wolf H. Fridman,Wolf H. Fridman,Wolf H. Fridman,Christoph Becker,Franck Pagès,Michael R. Speicher,Zlatko Trajanoski,Jérôme Galon +30 more
TL;DR: The immune landscape in human colorectal cancer is revealed and the major hallmarks of the microenvironment associated with tumor progression and recurrence are revealed.
Journal ArticleDOI
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
Franck Pagès,Anne Berger,Matthieu Camus,Fátima Sánchez-Cabo,Anne Costes,Robert Molidor,Bernhard Mlecnik,Amos Kirilovsky,Malin Nilsson,Diane Damotte,Tchao Meatchi,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Jérôme Galon +15 more
TL;DR: Signs of an immune response within colorectal cancers are associated with the absence of pathological evidence of early metastatic invasion and with prolonged survival.
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Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction
Philippe Menasché,Albert Hagège,Jean-Thomas Vilquin,Michel Desnos,Eric Abergel,Bruno Pouzet,Alain Bel,Sorin Sarateanu,Marcio Scorsin,Ketty Schwartz,Patrick Bruneval,Marc Benbunan,Jean-Pierre Marolleau,Denis Duboc +13 more
TL;DR: These preliminary data suggest the feasibility and safety of autologous skeletal myoblast transplantation in severe ischemic cardiomyopathy, with the caveat of an arrhythmogenic potential, and new-onset contraction of akinetic and nonviable segments suggests a functional efficacy that requires confirmation by randomized studies.
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Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer
Marie Tosolini,Amos Kirilovsky,Bernhard Mlecnik,Tessa Fredriksen,Stéphanie Mauger,Gabriela Bindea,Anne Berger,Patrick Bruneval,Wolf H. Fridman,Franck Pagès,Jérôme Galon +10 more
TL;DR: It is argued that functional Th1 and Th17 clusters yield opposite effects on patient survival in colorectal cancer, and they provide complementary information that may improve prognosis.