O
Olivier Blanc-Brude
Researcher at French Institute of Health and Medical Research
Publications - 51
Citations - 3665
Olivier Blanc-Brude is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Angiogenesis & Apoptosis. The author has an hindex of 25, co-authored 49 publications receiving 3241 citations. Previous affiliations of Olivier Blanc-Brude include University College London & Paris Descartes University.
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Journal ArticleDOI
Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
Stella Cosenza,Karine Toupet,Marie Maumus,Patricia Luz-Crawford,Olivier Blanc-Brude,Christian Jorgensen,Christian Jorgensen,Danièle Noël,Danièle Noël +8 more
TL;DR: This work is the first demonstration of the therapeutic potential of MSCs-derived EVs in inflammatory arthritis and exerts an anti-inflammatory role on T and B lymphocytes independently of M SCs priming.
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Lactadherin promotes VEGF-dependent neovascularization
Jean-Sébastien Silvestre,Clotilde Théry,Ghislaine Hamard,Jacques Boddaert,Barbara Aguilar,Alain Delcayre,Christophe Houbron,Radia Tamarat,Olivier Blanc-Brude,Sylvia Heeneman,Michel Clergue,Micheline Duriez,Régine Merval,Bernard I. Levy,Alain Tedgui,Sebastian Amigorena,Ziad Mallat +16 more
TL;DR: It is shown that an integrin-binding protein initially described in milk-fat globule, MFG-E8 (also known as lactadherin), is expressed in and around blood vessels and has a crucial role in VEGF-dependent neovascularization in the adult mouse.
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Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice.
Hafid Ait-Oufella,Kiyoka Kinugawa,Joffrey Zoll,Tabassome Simon,Jacques Boddaert,Silvia Heeneman,Olivier Blanc-Brude,Véronique Barateau,Stephane Potteaux,Régine Merval,Bruno Esposito,Elisabeth Teissier,Mat J.A.P. Daemen,Guy Lesèche,Chantal M. Boulanger,Alain Tedgui,Ziad Mallat +16 more
TL;DR: Lack of Mfge8 in bone marrow–derived cells enhances the accumulation of apoptotic cell corpses in atherosclerosis and alters the protective immune response, which leads to an acceleration of plaque development.
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Thrombin Is a Potent Inducer of Connective Tissue Growth Factor Production via Proteolytic Activation of Protease-activated Receptor-1
Rachel C. Chambers,Patricia Leoni,Olivier Blanc-Brude,David E. Wembridge,Geoffrey J. Laurent +4 more
TL;DR: It is proposed that coagulation proteases and PAR-1 may play a role in promoting connective tissue formation during normal tissue repair and the development of fibrosis by up-regulating fibroblast CTGF expression.
Journal Article
Therapeutic Targeting of the Survivin Pathway in Cancer Initiation of Mitochondrial Apoptosis and Suppression of Tumor-associated Angiogenesis
TL;DR: Survivin functions as a novel upstream regulator of mitochondrial-dependent apoptosis, and molecular targeting of this pathway results in anticancer activity via a dual mechanism of induction of tumor cell apoptosis and suppression of angiogenesis.