O
Olli Helminen
Researcher at Oulu University Hospital
Publications - 83
Citations - 871
Olli Helminen is an academic researcher from Oulu University Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 59 publications receiving 580 citations. Previous affiliations of Olli Helminen include University of Oulu.
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Journal ArticleDOI
Tumour-stroma ratio and prognosis in gastric adenocarcinoma.
Niko Kemi,Maarit Eskuri,Anni Herva,Joni Leppänen,Heikki Huhta,Olli Helminen,Juha Saarnio,Tuomo J. Karttunen,Joonas H. Kauppila,Joonas H. Kauppila +9 more
TL;DR: High proportion of stroma is an independent prognostic factor in both intestinal and diffuse histological subtypes of gastric adenocarcinoma.
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High immune cell score predicts improved survival in pancreatic cancer
Kyösti Tahkola,Jukka-Pekka Mecklin,Erkki-Ville Wirta,Maarit Ahtiainen,Olli Helminen,Jan Böhm,Ilmo Kellokumpu +6 more
TL;DR: Immune cell score was shown to be an independent prognostic factor for better DSS and OS in multivariate analysis, together with the histological grade of the tumor and perineural invasion, and could be a useful prognostic marker in patients with PDAC treated by primary surgery.
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Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett's esophagus, dysplasia and adenocarcinoma.
Heikki Huhta,Olli Helminen,Petri Lehenkari,Juha Saarnio,Juha Saarnio,Tuomo J. Karttunen,Tuomo J. Karttunen,Joonas H. Kauppila +7 more
TL;DR: Evaluated Toll-like receptors that sense bacterial cell wall components in Barrett's esophagus, dysplasia and esophageal adenocarcinoma found TLR1,TLR2, TLR4 and TLR6 expression are upregulated during malignant changes of esophages columnar epithelium.
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HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk
Olli Helminen,Susanna Aspholm,Tytti Pokka,Milla-Riikka Hautakangas,Nora Haatanen,Johanna Lempainen,Johanna Lempainen,Jorma Ilonen,Jorma Ilonen,Olli Simell,Mikael Knip,Riitta Veijola +11 more
TL;DR: HbA1c is a useful biochemical marker when predicting the time to diagnosis of type 1 diabetes in children with multiple autoantibodies, and is effective in predicting the timing of diagnosis.
Journal ArticleDOI
The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer
Heikki Huhta,Olli Helminen,Joonas H. Kauppila,Tuula Salo,Katja Porvari,Juha Saarnio,Petri Lehenkari,Tuomo J. Karttunen +7 more
TL;DR: Species from cancer patients’ normal tumor-adjacent tissue can be used as control tissues in immunohistochemical TLR studies in gastrointestinal cancer and normal epithelium adjacent to tumor seems to have similar TLR expression compared with healthy tissues suggesting absence of any field effect.