O
Orapan Sripichai
Researcher at Mahidol University
Publications - 25
Citations - 570
Orapan Sripichai is an academic researcher from Mahidol University. The author has contributed to research in topics: Thalassemia & Fetal hemoglobin. The author has an hindex of 10, co-authored 19 publications receiving 477 citations. Previous affiliations of Orapan Sripichai include Thailand Ministry of Public Health.
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Journal ArticleDOI
A genome-wide association identified the common genetic variants influence disease severity in β0-thalassemia/hemoglobin E
Manit Nuinoon,Wattanan Makarasara,Taisei Mushiroda,Iswari Setianingsih,Pustika Amalia Wahidiyat,Orapan Sripichai,Natsuhiko Kumasaka,Atsushi Takahashi,Saovaros Svasti,Thongperm Munkongdee,Surakameth Mahasirimongkol,Chayanon Peerapittayamongkol,Vip Viprakasit,Naoyuki Kamatani,Pranee Winichagoon,Michiaki Kubo,Yusuke Nakamura,Suthat Fucharoen +17 more
TL;DR: It is revealed that all the three reported loci and the α-globin gene locus are the best and common predictors of the disease severity in β-thalassemia.
Journal ArticleDOI
A scoring system for the classification of β-thalassemia/Hb E disease severity
Orapan Sripichai,Wattanan Makarasara,Thongperm Munkongdee,Chutima Kumkhaek,Issarang Nuchprayoon,Ampaiwan Chuansumrit,Suporn Chuncharunee,Nawarat Chantrakoon,Piathip Boonmongkol,Pranee Winichagoon,Suthat Fucharoen +10 more
TL;DR: The phenotypic diversity of 950 β‐thalassemia/Hb E patients was examined in an attempt to construct a system for classifying disease severity, which was able to separate patients into three distinctive severity categories: mild, moderate, and severe courses.
Journal ArticleDOI
Coinheritance of the different copy numbers of α-globin gene modifies severity of β-thalassemia/Hb E disease
Orapan Sripichai,Thongperm Munkongdee,Chutima Kumkhaek,Saovaros Svasti,Pranee Winichagoon,Suthat Fucharoen +5 more
TL;DR: This finding demonstrates that the genetic combination leading to the more/less degree of α- to non-α-globin chains imbalance is indeed the cause of the severe/mild thalassemia phenotype.
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Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches.
TL;DR: This article will review the heterogeneity and genetic modifiers of HfF and HbF induction therapy in β-thalassemia and suggest further understanding of Hbf level variation and regulation is needed in order to predict the response from H bF-inducing approaches.
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β‐Globin gene cluster polymorphisms are strongly associated with severity of HbE/β0‐thalassemia
Qianli Ma,Ken Abel,Orapan Sripichai,J Whitacre,Vach Angkachatchai,W Makarasara,Pranee Winichagoon,Suthat Fucharoen,Andreas Braun,Lindsay A. Farrer +9 more
TL;DR: Haplotype analysis revealed that the T allele of XmnI was nearly always in cis with the HbE allele, suggesting that the high frequency of this haplotype may be favored by positive selection against malarial infection.