O
Ossama El-Kabbani
Researcher at Monash University, Parkville campus
Publications - 59
Citations - 1625
Ossama El-Kabbani is an academic researcher from Monash University, Parkville campus. The author has contributed to research in topics: Active site & Reductase. The author has an hindex of 23, co-authored 59 publications receiving 1509 citations.
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Journal ArticleDOI
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
Gustavo Fenalti,Ruby H. P. Law,Ashley M. Buckle,Christopher G. Langendorf,Kellie L. Tuck,Carlos J. Rosado,Noel G. Faux,Khalid Mahmood,Christiane S. Hampe,J. P. Banga,Matthew C.J. Wilce,Jason W. Schmidberger,Jamie Rossjohn,Ossama El-Kabbani,Robert N. Pike,A.I. Smith,Ian R. Mackay,Merrill J. Rowley,James C. Whisstock +18 more
TL;DR: Kinetic studies suggest that mobility in the catalytic loop promotes a side reaction that results in cofactor release and GAD65 autoinactivation, and these data reveal the molecular basis for regulation of GABA homeostasis.
Journal ArticleDOI
Aldose reductase structures: implications for mechanism and inhibition.
TL;DR: An overview of the proposed catalytic mechanism and structures of the current inhibitors complexed with ALR2 are provided and the current state of structure-based drug design is provided.
Journal ArticleDOI
Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with fidarestat and minalrestat: Implications for the binding of cyclic imide inhibitors
Ossama El-Kabbani,Connie Darmanin,Thomas R. Schneider,Isabelle Hazemann,Federico M. Ruiz,Mitsuru Oka,A. Joachimiak,Clemens Schulze-Briese,Takashi Tomizaki,Andre Mitschler,Alberto Podjarny +10 more
TL;DR: Observations suggest a mechanism in which Fidarestat is bound protonated and becomes negatively charged by donating the proton to His110, which may have important implications on drug design.
Journal ArticleDOI
Selective and potent inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone
TL;DR: In the efforts to identify agents that would specifically inhibit the two enzymes, benzbromarone and 3',3",5',5"-tetrabromophenolphthalein were found to be relatively selective and potent inhibitors of AKR1C1.
Journal ArticleDOI
Sorbitol Dehydrogenase: Structure, Function and Ligand Design
TL;DR: The available structural and biochemical information of SDH are currently being utilized in a structure-based approach to develop drugs for the treatment or prevention of the complications of diabetes.