O
Owen S. Fenton
Researcher at Massachusetts Institute of Technology
Publications - 47
Citations - 3445
Owen S. Fenton is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Catalysis & In vivo. The author has an hindex of 22, co-authored 41 publications receiving 2295 citations. Previous affiliations of Owen S. Fenton include College of the Holy Cross & National University of Singapore.
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Journal ArticleDOI
Advances in Biomaterials for Drug Delivery.
TL;DR: Advances in biomaterials for drug delivery are enabling significant progress in biology and medicine, including major breakthroughs in materials for cancer immunotherapy, autoimmune diseases, and genome editing.
Journal ArticleDOI
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
Matthias A. Oberli,Andreas M. Reichmuth,J. Robert Dorkin,Michael J. Mitchell,Owen S. Fenton,Ana Jaklenec,Daniel G. Anderson,Robert Langer,Daniel Blankschtein +8 more
TL;DR: The lipid nanoparticle formulation presented here is a promising vector for mRNA vaccine delivery, one that is capable of inducing a strong cytotoxic T cell response and further optimization, including the incorporation of different adjuvants, will likely enhance the potency of the vaccine.
Journal ArticleDOI
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.
Kevin J. Kauffman,J. Robert Dorkin,Jung H. Yang,Michael W. Heartlein,Frank Derosa,Faryal F. Mir,Owen S. Fenton,Daniel G. Anderson +7 more
TL;DR: An optimized formulation which increased the potency of erythropoietin-mRNA-loaded C12-200 lipid nanoparticles 7-fold relative to formulations previously used for siRNA delivery and increased ionizable lipid:mRNA weight ratios was developed.
Journal ArticleDOI
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.
Kathryn A. Whitehead,J. Robert Dorkin,Arturo J. Vegas,Philip H. Chang,Omid Veiseh,Jonathan Matthews,Owen S. Fenton,Yunlong Zhang,Karsten Olejnik,Volkan Yesilyurt,Delai Chen,Scott A Barros,Boris Klebanov,Tatiana Novobrantseva,Robert Langer,Daniel G. Anderson +15 more
TL;DR: It is shown that lipidoid nanoparticles mediate potent gene knockdown in hepatocytes and immune cell populations upon IV administration to mice (siRNA EC50 values as low as 0.01 mg/kg); new design criteria that reliably predict in vivo siRNA delivery efficacy without any prior biological testing are described.
Journal ArticleDOI
Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs.
James C. Kaczmarek,Asha K. Patel,Asha K. Patel,Kevin J. Kauffman,Owen S. Fenton,Matthew J. Webber,Michael W. Heartlein,Frank Derosa,Daniel G. Anderson +8 more
TL;DR: The formulations were capable of functional delivery of mRNA to the lungs after intravenous administration in mice and are the first report of the systemic administration of mRNA for delivery to the lung using degradable polymer-lipid nanoparticles.