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Michael J. Mitchell

Researcher at University of Pennsylvania

Publications -  224
Citations -  13412

Michael J. Mitchell is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 51, co-authored 180 publications receiving 8609 citations. Previous affiliations of Michael J. Mitchell include University of Western Ontario & Massachusetts Institute of Technology.

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Engineering precision nanoparticles for drug delivery

Michael J. Mitchell, +5 more
- 01 Feb 2021 - 
TL;DR: Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.
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Delivery technologies for cancer immunotherapy

Rachel S. Riley, +3 more
- 01 Mar 2019 - 
TL;DR: How recent developments in drug delivery could enable new cancer immunotherapies and improve on existing ones are discussed, and the current delivery obstacles are examined.
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Advances in Biomaterials for Drug Delivery.

Owen S. Fenton, +4 more
- 01 Jul 2018 - 
TL;DR: Advances in biomaterials for drug delivery are enabling significant progress in biology and medicine, including major breakthroughs in materials for cancer immunotherapy, autoimmune diseases, and genome editing.
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Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

Matthias A. Oberli, +8 more
- 08 Mar 2017 - 
TL;DR: The lipid nanoparticle formulation presented here is a promising vector for mRNA vaccine delivery, one that is capable of inducing a strong cytotoxic T cell response and further optimization, including the incorporation of different adjuvants, will likely enhance the potency of the vaccine.
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Pachytene Asynapsis Drives Meiotic Sex Chromosome Inactivation and Leads to Substantial Postmeiotic Repression in Spermatids

James M. A. Turner, +4 more
- 01 Apr 2006 - 
TL;DR: This work provides direct evidence that asynapsis does indeed drive MSCI, and shows that a substantial degree of transcriptional repression of the sex chromosomes is retained postmeiotically, and provides evidence that this postmeiotic repression is a downstream consequence of MSCi/MSUC.