M
Matthias A. Oberli
Researcher at Massachusetts Institute of Technology
Publications - 33
Citations - 2092
Matthias A. Oberli is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Immune system & Borylation. The author has an hindex of 18, co-authored 31 publications receiving 1519 citations. Previous affiliations of Matthias A. Oberli include Max Planck Society & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
Matthias A. Oberli,Andreas M. Reichmuth,J. Robert Dorkin,Michael J. Mitchell,Owen S. Fenton,Ana Jaklenec,Daniel G. Anderson,Robert Langer,Daniel Blankschtein +8 more
TL;DR: The lipid nanoparticle formulation presented here is a promising vector for mRNA vaccine delivery, one that is capable of inducing a strong cytotoxic T cell response and further optimization, including the incorporation of different adjuvants, will likely enhance the potency of the vaccine.
Journal ArticleDOI
mRNA vaccine delivery using lipid nanoparticles.
TL;DR: Among potential nonviral vectors, lipid nanoparticles are particularly promising, and can be synthesized with relative ease in a scalable manner, protect the mRNA against degradation, facilitate endosomal escape, and as needed, can be codelivered with adjuvants.
Journal ArticleDOI
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Jatin Roper,Jatin Roper,Tuomas Tammela,Naniye Malli Cetinbas,Adam Akkad,Ali Roghanian,Ali Roghanian,Steffen Rickelt,Mohammad Almeqdadi,Katherine Wu,Matthias A. Oberli,Francisco J. Sánchez-Rivera,Yoona K Park,Xu Liang,George Eng,George Eng,Martin S. Taylor,Roxana Azimi,Dmitriy Kedrin,Rachit Neupane,Semir Beyaz,Ewa Sicinska,Yvelisse Suarez,James J. Yoo,Lillian Chen,Lawrence R. Zukerberg,Pekka Katajisto,Pekka Katajisto,Vikram Deshpande,Adam J. Bass,Philip N. Tsichlis,Jacqueline A. Lees,Robert Langer,Richard O. Hynes,Jianzhu Chen,Arjun Bhutkar,Tyler Jacks,Ömer H. Yilmaz,Ömer H. Yilmaz +38 more
TL;DR: In this article, the authors describe approaches to model colorectal cancer and metastasis, which rely on in situ gene editing and orthotopic organoid transplantation in mice without cancer-predisposing mutations.
Journal ArticleDOI
Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes
Owen S. Fenton,Kevin J. Kauffman,James C. Kaczmarek,Rebecca L. McClellan,Siddharth Jhunjhunwala,Mark W. Tibbitt,Manhao D. Zeng,Eric A. Appel,Joseph R. Dorkin,Faryal F. Mir,Jung H. Yang,Matthias A. Oberli,Michael W. Heartlein,Frank Derosa,Robert Langer,Daniel G. Anderson +15 more
TL;DR: It is demonstrated that LNP composition alone can be used to modulate the site of protein induction in vivo, highlighting the critical importance of designing and synthesizing new nanomaterials for nucleic acid delivery.
Journal ArticleDOI
A possible oligosaccharide-conjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic.
Matthias A. Oberli,Marie-Lyn Hecht,Pascal Bindschädler,Alexander Adibekian,Thomas Adam,Peter H. Seeberger,Peter H. Seeberger +6 more
TL;DR: It is found that specific IgA antibodies in the stool of hospital patients infected with C. difficile recognize the synthetic PS-II hexasaccharide hapten, as determined by microarray analysis.