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Özer Degistirici
Researcher at University of Düsseldorf
Publications - 14
Citations - 1594
Özer Degistirici is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 9, co-authored 12 publications receiving 1494 citations.
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Journal ArticleDOI
A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential
Gesine Kögler,Sandra Sensken,Judith A. Airey,Thorsten Trapp,Markus Müschen,Niklas Feldhahn,Stefanie Liedtke,Rüdiger V. Sorg,Johannes C. Fischer,Claudia Rosenbaum,Susanne Greschat,Andreas Knipper,Jörg Bender,Özer Degistirici,Jizong Gao,Arnold I. Caplan,Evan Colletti,Graça Almeida-Porada,Hans Werner Müller,Esmail D. Zanjani,Peter Wernet +20 more
TL;DR: A new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described, which grows adherently and can be expanded to 1015 cells without losing pluripotency.
Journal ArticleDOI
Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase
Roland Meisel,Brockers S,Kathrin Heseler,Özer Degistirici,Bülle H,Claudia Woite,Stuhlsatz S,Schwippert W,Marcus Jäger,Rüdiger V. Sorg,Reinhard Henschler,Jochen Seissler,Dagmar Dilloo,Dagmar Dilloo,Walter Däubener +14 more
TL;DR: The data identify human MSC as a cellular immunosuppressant that concurrently exhibits potent antimicrobial effector function thus encouraging their further evaluation in clinical trials.
Journal ArticleDOI
Bone Healing and Migration of Cord Blood—Derived Stem Cells Into a Critical Size Femoral Defect After Xenotransplantation
Marcus Jäger,Marcus Jäger,Özer Degistirici,Andreas Knipper,Johannes C. Fischer,Martin Sager,Rüdiger Krauspe +6 more
TL;DR: This study supports the application of cord blood stem cells for bone regeneration by finding a survival of human cells within the scaffold and surrounding bone/bone marrow up to 4 wk after transplantation and an increased bone healing rate compared with controls without stem cells.
Journal ArticleDOI
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
Lucas-Sebastian Spitzhorn,Matthias Megges,Wasco Wruck,Shaifur Rahman,Jörg Otte,Özer Degistirici,Roland Meisel,Rüdiger V. Sorg,Richard O.C. Oreffo,James Adjaye +9 more
TL;DR: iMSCs irrespective of donor age and cell source acquire a rejuvenation gene signature, which could allow circumventing the drawbacks associated with the use of adult MSCs und thus provide a promising tool for use in various clinical settings in the future.
Journal ArticleDOI
Cytomegalovirus infection impairs immunosuppressive and antimicrobial effector functions of human multipotent mesenchymal stromal cells.
Roland Meisel,Kathrin Heseler,Julia Nau,Silvia K. Schmidt,M. Leineweber,Sabine Pudelko,Johannes Wenning,Albert Zimmermann,Hartmut Hengel,Christian Sinzger,Özer Degistirici,Rüdiger V. Sorg,Walter Däubener +12 more
TL;DR: It is demonstrated that CMV-infected MSC lose their cytokine-induced immunosuppressive capacity and are no longer able to restrict microbial growth.